This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
Sandbox SouthUniversity3
From Proteopedia
(Difference between revisions)
| Line 8: | Line 8: | ||
One strand of human DNA can be seen here <scene name='Sandbox_SouthUniversity3/Human-viral_dna_ribbon/3'>highlighted in green</scene> | One strand of human DNA can be seen here <scene name='Sandbox_SouthUniversity3/Human-viral_dna_ribbon/3'>highlighted in green</scene> | ||
| - | The drug raltegravir (Isentress)is the first drug that has made its way to market that acts as an inhibitor of HIV-integrase. It is shown <scene name='Sandbox_SouthUniversity3/ | + | The drug raltegravir (Isentress)is the first drug that has made its way to market that acts as an inhibitor of HIV-integrase. It is shown <scene name='Sandbox_SouthUniversity3/Isentress_spacefill/1'>here</scene> displayed in a space filling representation.It is easier to see the functional groups displayed as <scene name='Sandbox_SouthUniversity3/Isentress_sticks/1'>sticks</scene> |
| + | |||
| + | Note the 3 oxygen atoms labeled <scene name='Sandbox_SouthUniversity3/Isentress_oxy_label/2'>here</scene>. They are a vital part of the structure, since they bind (chelate) to 2 magnesium ions within the enzyme. | ||
</StructureSection> | </StructureSection> | ||
Revision as of 14:31, 18 April 2012
==Integrase as an anti-HIV drug target==
| |||||||||||
