1lsl
From Proteopedia
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==Overview== | ==Overview== | ||
| - | Thrombospondin-1 (TSP-1) contains three type 1 repeats (TSRs), which | + | Thrombospondin-1 (TSP-1) contains three type 1 repeats (TSRs), which mediate cell attachment, glycosaminoglycan binding, inhibition of angiogenesis, activation of TGFbeta, and inhibition of matrix metalloproteinases. The crystal structure of the TSRs reported in this article reveals a novel, antiparallel, three-stranded fold that consists of alternating stacked layers of tryptophan and arginine residues from respective strands, capped by disulfide bonds on each end. The front face of the TSR contains a right-handed spiral, positively charged groove that might be the "recognition" face, mediating interactions with various ligands. This is the first high-resolution crystal structure of a TSR domain that provides a prototypic architecture for structural and functional exploration of the diverse members of the TSR superfamily. |
==Disease== | ==Disease== | ||
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[[Category: Liu, J.]] | [[Category: Liu, J.]] | ||
[[Category: Tan, K.]] | [[Category: Tan, K.]] | ||
| - | [[Category: Wang, J | + | [[Category: Wang, J H.]] |
[[Category: Zhang, R.]] | [[Category: Zhang, R.]] | ||
[[Category: FUC]] | [[Category: FUC]] | ||
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[[Category: tsr]] | [[Category: tsr]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:48:02 2008'' |
Revision as of 11:48, 21 February 2008
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Crystal Structure of the Thrombospondin-1 Type 1 Repeats
Contents |
Overview
Thrombospondin-1 (TSP-1) contains three type 1 repeats (TSRs), which mediate cell attachment, glycosaminoglycan binding, inhibition of angiogenesis, activation of TGFbeta, and inhibition of matrix metalloproteinases. The crystal structure of the TSRs reported in this article reveals a novel, antiparallel, three-stranded fold that consists of alternating stacked layers of tryptophan and arginine residues from respective strands, capped by disulfide bonds on each end. The front face of the TSR contains a right-handed spiral, positively charged groove that might be the "recognition" face, mediating interactions with various ligands. This is the first high-resolution crystal structure of a TSR domain that provides a prototypic architecture for structural and functional exploration of the diverse members of the TSR superfamily.
Disease
Known disease associated with this structure: Sudden infant death with dysgenesis of the testes syndrome OMIM:[604714]
About this Structure
1LSL is a Single protein structure of sequence from Homo sapiens with and as ligands. Full crystallographic information is available from OCA.
Reference
Crystal structure of the TSP-1 type 1 repeats: a novel layered fold and its biological implication., Tan K, Duquette M, Liu JH, Dong Y, Zhang R, Joachimiak A, Lawler J, Wang JH, J Cell Biol. 2002 Oct 28;159(2):373-82. Epub 2002 Oct 21. PMID:12391027
Page seeded by OCA on Thu Feb 21 13:48:02 2008
Categories: Homo sapiens | Single protein | Dong, Y. | Duquette, M. | Joachimiak, A. | Lawler, J. | Liu, J. | Tan, K. | Wang, J H. | Zhang, R. | FUC | FUL | Tsp-1 | Tsr
