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4ef0
From Proteopedia
(Difference between revisions)
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| - | + | {{STRUCTURE_4ef0| PDB=4ef0 | SCENE= }} | |
| + | ===Crystal Structure of the first catalytic domain of protein disulfide isomerase P5=== | ||
| - | + | ==Function== | |
| + | [[http://www.uniprot.org/uniprot/PDIA6_HUMAN PDIA6_HUMAN]] May function as a chaperone that inhibits aggregation of misfolded proteins. Plays a role in platelet aggregation and activation by agonists such as convulxin, collagen and thrombin.<ref>PMID:15466936</ref> <ref>PMID:12204115</ref> | ||
| - | + | ==About this Structure== | |
| + | [[4ef0]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EF0 OCA]. | ||
| - | + | ==Reference== | |
| + | <references group="xtra"/><references/> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Protein disulfide-isomerase]] | ||
| + | [[Category: Gehring, K.]] | ||
| + | [[Category: Kozlov, G.]] | ||
| + | [[Category: Vinaik, R.]] | ||
| + | [[Category: Bip]] | ||
| + | [[Category: Disulfide bond isomerization]] | ||
| + | [[Category: Endoplasmic reticulum]] | ||
| + | [[Category: Isomerase]] | ||
| + | [[Category: Thioredoxin-like fold]] | ||
Revision as of 01:47, 4 April 2013
Contents |
Crystal Structure of the first catalytic domain of protein disulfide isomerase P5
Function
[PDIA6_HUMAN] May function as a chaperone that inhibits aggregation of misfolded proteins. Plays a role in platelet aggregation and activation by agonists such as convulxin, collagen and thrombin.[1] [2]
About this Structure
4ef0 is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- ↑ Jordan PA, Stevens JM, Hubbard GP, Barrett NE, Sage T, Authi KS, Gibbins JM. A role for the thiol isomerase protein ERP5 in platelet function. Blood. 2005 Feb 15;105(4):1500-7. Epub 2004 Oct 5. PMID:15466936 doi:10.1182/blood-2004-02-0608
- ↑ Kikuchi M, Doi E, Tsujimoto I, Horibe T, Tsujimoto Y. Functional analysis of human P5, a protein disulfide isomerase homologue. J Biochem. 2002 Sep;132(3):451-5. PMID:12204115
