3vpp
From Proteopedia
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{{STRUCTURE_3vpp| PDB=3vpp | SCENE= }} | {{STRUCTURE_3vpp| PDB=3vpp | SCENE= }} | ||
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===Crystal Structure of the Human CLEC9A C-type Lectin-Like Domain=== | ===Crystal Structure of the Human CLEC9A C-type Lectin-Like Domain=== | ||
| + | {{ABSTRACT_PUBMED_22483802}} | ||
| - | + | ==Function== | |
| - | + | [[http://www.uniprot.org/uniprot/CLC9A_HUMAN CLC9A_HUMAN]] Functions as an endocytic receptor on a small subset of myeloid cells specialized for the uptake and processing of material from dead cells. Recognizes filamentous form of actin in association with particular actin-binding domains of cytoskeletal proteins, including spectrin, exposed when cell membranes are damaged, and mediate the cross-presentation of dead-cell associated antigens in a Syk-dependent manner.<ref>PMID:18497879</ref> <ref>PMID:22483802</ref> | |
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==About this Structure== | ==About this Structure== | ||
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==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID:022483802</ref><references group="xtra"/> | + | <ref group="xtra">PMID:022483802</ref><references group="xtra"/><references/> |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Colman, P M.]] | [[Category: Colman, P M.]] | ||
Revision as of 03:45, 1 August 2013
Contents |
Crystal Structure of the Human CLEC9A C-type Lectin-Like Domain
Template:ABSTRACT PUBMED 22483802
Function
[CLC9A_HUMAN] Functions as an endocytic receptor on a small subset of myeloid cells specialized for the uptake and processing of material from dead cells. Recognizes filamentous form of actin in association with particular actin-binding domains of cytoskeletal proteins, including spectrin, exposed when cell membranes are damaged, and mediate the cross-presentation of dead-cell associated antigens in a Syk-dependent manner.[1] [2]
About this Structure
3vpp is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Zhang JG, Czabotar PE, Policheni AN, Caminschi I, San Wan S, Kitsoulis S, Tullett KM, Robin AY, Brammananth R, van Delft MF, Lu J, O'Reilly LA, Josefsson EC, Kile BT, Chin WJ, Mintern JD, Olshina MA, Wong W, Baum J, Wright MD, Huang DC, Mohandas N, Coppel RL, Colman PM, Nicola NA, Shortman K, Lahoud MH. The Dendritic Cell Receptor Clec9A Binds Damaged Cells via Exposed Actin Filaments. Immunity. 2012 Apr 20;36(4):646-57. Epub 2012 Apr 5. PMID:22483802 doi:10.1016/j.immuni.2012.03.009
- ↑ Sancho D, Mourao-Sa D, Joffre OP, Schulz O, Rogers NC, Pennington DJ, Carlyle JR, Reis e Sousa C. Tumor therapy in mice via antigen targeting to a novel, DC-restricted C-type lectin. J Clin Invest. 2008 Jun;118(6):2098-110. doi: 10.1172/JCI34584. PMID:18497879 doi:10.1172/JCI34584
- ↑ Zhang JG, Czabotar PE, Policheni AN, Caminschi I, San Wan S, Kitsoulis S, Tullett KM, Robin AY, Brammananth R, van Delft MF, Lu J, O'Reilly LA, Josefsson EC, Kile BT, Chin WJ, Mintern JD, Olshina MA, Wong W, Baum J, Wright MD, Huang DC, Mohandas N, Coppel RL, Colman PM, Nicola NA, Shortman K, Lahoud MH. The Dendritic Cell Receptor Clec9A Binds Damaged Cells via Exposed Actin Filaments. Immunity. 2012 Apr 20;36(4):646-57. Epub 2012 Apr 5. PMID:22483802 doi:10.1016/j.immuni.2012.03.009
