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3ujm
From Proteopedia
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| - | [[ | + | ==Crystal structure of the NTF2-like domain of the Drosophila melanogaster Rasputin protein== |
| + | <StructureSection load='3ujm' size='340' side='right' caption='[[3ujm]], [[Resolution|resolution]] 2.74Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[3ujm]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UJM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3UJM FirstGlance]. <br> | ||
| + | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene><br> | ||
| + | <tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">rin, CG9412 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7227 Drosophila melanogaster])</td></tr> | ||
| + | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ujm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ujm OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ujm RCSB], [http://www.ebi.ac.uk/pdbsum/3ujm PDBsum]</span></td></tr> | ||
| + | <table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | The crystal structure of the NTF2-like domain of the Drosophila homolog of Ras GTPase SH3 Binding Protein (G3BP), Rasputin, was determined at 2.7A resolution. The overall structure is highly similar to nuclear transport factor 2: It is a homodimer comprised of a beta-sheet and three alpha-helices forming a cone-like shape. However, known binding sites for RanGDP and FxFG containing peptides show electrostatic and steric differences compared to nuclear transport factor 2. A HEPES molecule bound in the structure suggests a new, and possibly physiologically relevant, ligand binding site. | ||
| - | + | Crystal structure of the Rasputin NTF2-like domain from Drosophila melanogaster.,Vognsen T, Kristensen O Biochem Biophys Res Commun. 2012 Mar 30;420(1):188-92. Epub 2012 Mar 3. PMID:22414690<ref>PMID:22414690</ref> | |
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| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | + | </div> | |
| - | + | == References == | |
| - | + | <references/> | |
| - | + | __TOC__ | |
| - | + | </StructureSection> | |
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[[Category: Drosophila melanogaster]] | [[Category: Drosophila melanogaster]] | ||
[[Category: Kristensen, O.]] | [[Category: Kristensen, O.]] | ||
Revision as of 06:38, 5 June 2014
Crystal structure of the NTF2-like domain of the Drosophila melanogaster Rasputin protein
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