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Sandbox Reserved 479

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==Structure==
==Structure==
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<Structure load='2mys' size='350' frame='true' align='right' caption='2mys ribbon-diagram' scene='Insert optional scene name here' />
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<Structure load='2mys' size='250' frame='true' align='right' caption='2mys ribbon-diagram' scene='Insert optional scene name here' />
====Oligomeric State====
====Oligomeric State====

Revision as of 02:10, 26 April 2012

This Sandbox is Reserved from 13/03/2012, through 01/06/2012 for use in the course "Proteins and Molecular Mechanisms" taught by Robert B. Rose at the North Carolina State University, Raleigh, NC USA. This reservation includes Sandbox Reserved 451 through Sandbox Reserved 500.
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Myosin is comprised of 35 different classes of motor proteins, and is universal in all eukaryotic cells.

Contents

Structure

2mys ribbon-diagram

Drag the structure with the mouse to rotate

Oligomeric State

Secondary Structure

Active Site

Ligands

X-Ray Crystallography

Mechanism of Action

Myosin plays a role in the universal mechanism known as the actinomysin chemomechanical cycle. Actin binds and releases myosin, causing the myosin lever to interact and relax in a cyclic manner.[1]

Medical Implications or Possible Applications

References

[2]

  1. ↑ Varkuti BH, Yang Z, Kintses B, Erdelyi P, Bardos-Nagy I, Kovacs AL, Hari P, Kellermayer M, Vellai T, Malnasi-Csizmadia A. A novel actin binding site of myosin required for effective muscle contraction. Nat Struct Mol Biol. 2012 Feb 12;19(3):299-306. doi: 10.1038/nsmb.2216. PMID:22343723 doi:10.1038/nsmb.2216
  2. ↑ Ruppel KM, Spudich JA. Structure-function studies of the myosin motor domain: importance of the 50-kDa cleft. Mol Biol Cell. 1996 Jul;7(7):1123-36. PMID:8862525
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