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For more help, look at this link: http://www.proteopedia.org/wiki/index.php/Help:Getting_Started_in_Proteopedia Tubulin

Introduction

Tubulin is a globular protein. The most common types of tubulin are alpha and beta tubulin. Each portion has a molecular weight of about 55 kDa. Its main function is to create microtubules. The alpha and beta proteins polymerize to create the microtubule. Gama Tubulin is also an important tubulin protein. Tubulin is used in plants as well as animals. For plants, it is important for acentrosomal microtubule nucleation in plants. This can be shown in Arabidopsis. The gama tubulin protein binds with other proteins in order to create a “cap” at the negative end of the microtubule and acts as a scaffold for the alpha/beta tubulin dimer to polymerize.

Microtubules are important for maintaining cell structure. It provides platforms for intracellular transport, helps to form the spindle during mitosis, and also contributes to other cellular processes. Many viruses such as gemini-viruses can attack these proteins and cause cell death which leads to plant death. One particular study by Keech et al showed that Cabbage Leaf Curl Virus (CaLCuV) induced senescence in Arabidopsis plants which lead to plant death.

Structure

The picture shown is of the dimerized alpha and beta tubulin. Each part is important in creating the microtubule for plant growth. The alpha portion provides the negative end of the tubule while the beta end provided the positive end. The negative end is where the gamma tubulin attaches to so that the micotubule will only continue polymerizing on the positive end.

Mechanism of Action

Medical Implications or Possible Applications

Tubulin is an important protein related to plant growth. By understanding how Tubulin reacts to certain viruses, researchers can better understand how plants are affected by viruses. Once this is understood, researchers can possibly find ways to prevent cell and plant death.

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