Sandbox Reserved 480

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 2: Line 2:
{{Sandbox_Reserved_Robert_B_Rose_1}}
{{Sandbox_Reserved_Robert_B_Rose_1}}
<!-- PLEASE ADD YOUR CONTENT BELOW HERE -->
<!-- PLEASE ADD YOUR CONTENT BELOW HERE -->
-
 
+
[[file:2pah_bio_r_500.jpg|thumb|100px]]
== Phenylalanine Hydroxylase ==
== Phenylalanine Hydroxylase ==
<Structure load='1tg2' size='400' frame='true' align='right' caption='Phenylalanine Hydroxylase' scene='Phenylalanine Hydroxylase' />
<Structure load='1tg2' size='400' frame='true' align='right' caption='Phenylalanine Hydroxylase' scene='Phenylalanine Hydroxylase' />

Revision as of 14:06, 2 May 2012

This Sandbox is Reserved from 13/03/2012, through 01/06/2012 for use in the course "Proteins and Molecular Mechanisms" taught by Robert B. Rose at the North Carolina State University, Raleigh, NC USA. This reservation includes Sandbox Reserved 451 through Sandbox Reserved 500.
To get started:
  • Click the edit this page tab at the top. Save the page after each step, then edit it again.
  • Click the 3D button (when editing, above the wikitext box) to insert Jmol.
  • show the Scene authoring tools, create a molecular scene, and save it. Copy the green link into the page.
  • Add a description of your scene. Use the buttons above the wikitext box for bold, italics, links, headlines, etc.

More help: Help:Editing

For more help, look at this link: http://www.proteopedia.org/wiki/index.php/Help:Getting_Started_in_Proteopedia thumb|100px

Contents

Phenylalanine Hydroxylase

Phenylalanine Hydroxylase

Drag the structure with the mouse to rotate

Phenylalanine Hydroxylase()is a type of enzyme involved in the catalization of phenylalanine into tyrosine. It belongs to the family of aromatic amino acid hydroxylases. Some other enzymes in this family include tyrosine hydroxylase and tryptophan hydroxylase. These enzymes require oxygen and forms of pterin to convert their amino acid substrates into products.

Structure

PheOH is a tetrameric enzyme, consisting of 2 asymmetric components. It contains an It has been observed as a and tetrameric structure. This is the site within the subunit. This includes the residues His, His, and This enzyme has two , Fe (III) and .

Phenylketonuria

Phenylalanine hydroxylase is the rate limiting exzyme invovled in the metabolism of phenylalanine. With Fe (III), oxygen, and tetrahydrobiopterin, PheOH hydroxylates Phe into Tyr. Tyr goes on to make L-dopa and eventually dopamine.

Mechanism

References

Retrieved from "http://52.214.119.220/wiki/index.php/Sandbox_Reserved_480"
Personal tools