4agm
From Proteopedia
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[[Image:4agm.png|left|200px]] | [[Image:4agm.png|left|200px]] | ||
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{{STRUCTURE_4agm| PDB=4agm | SCENE= }} | {{STRUCTURE_4agm| PDB=4agm | SCENE= }} | ||
===Structure of the p53 core domain mutant Y220C bound to the stabilizing small molecule PhiKan5086=== | ===Structure of the p53 core domain mutant Y220C bound to the stabilizing small molecule PhiKan5086=== | ||
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{{ABSTRACT_PUBMED_22439615}} | {{ABSTRACT_PUBMED_22439615}} | ||
==About this Structure== | ==About this Structure== | ||
| - | [[4agm]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AGM OCA]. | + | [[4agm]] is a 2 chain structure of [[P53]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AGM OCA]. |
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| + | ==See Also== | ||
| + | *[[P53|P53]] | ||
==Reference== | ==Reference== | ||
Revision as of 11:20, 25 July 2012
Contents |
Structure of the p53 core domain mutant Y220C bound to the stabilizing small molecule PhiKan5086
Template:ABSTRACT PUBMED 22439615
About this Structure
4agm is a 2 chain structure of P53 with sequence from Homo sapiens. Full crystallographic information is available from OCA.
See Also
Reference
- Wilcken R, Liu X, Zimmermann MO, Rutherford TJ, Fersht AR, Joerger AC, Boeckler FM. Halogen-Enriched Fragment Libraries as Leads for Drug Rescue of Mutant p53. J Am Chem Soc. 2012 Apr 18;134(15):6810-8. Epub 2012 Apr 5. PMID:22439615 doi:10.1021/ja301056a
- Joerger AC, Ang HC, Fersht AR. Structural basis for understanding oncogenic p53 mutations and designing rescue drugs. Proc Natl Acad Sci U S A. 2006 Oct 10;103(41):15056-61. Epub 2006 Oct 2. PMID:17015838
