3qb1

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[[Image:3qb1.png|left|200px]]
 
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{{STRUCTURE_3qb1| PDB=3qb1 | SCENE= }}
{{STRUCTURE_3qb1| PDB=3qb1 | SCENE= }}
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===Interleukin-2 mutant D10===
===Interleukin-2 mutant D10===
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{{ABSTRACT_PUBMED_22446627}}
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==Disease==
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[[http://www.uniprot.org/uniprot/IL2_HUMAN IL2_HUMAN]] Note=A chromosomal aberration involving IL2 is found in a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(4;16)(q26;p13) with involves TNFRSF17.
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==Function==
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[[http://www.uniprot.org/uniprot/IL2_HUMAN IL2_HUMAN]] Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells.
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(as it appears on PubMed at http://www.pubmed.gov), where 22446627 is the PubMed ID number.
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{{ABSTRACT_PUBMED_22446627}}
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==About this Structure==
==About this Structure==
[[3qb1]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QB1 OCA].
[[3qb1]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QB1 OCA].
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==See Also==
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*[[Interleukin|Interleukin]]
==Reference==
==Reference==
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<ref group="xtra">PMID:022446627</ref><references group="xtra"/>
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<ref group="xtra">PMID:022446627</ref><references group="xtra"/><references/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Bates, D L.]]
[[Category: Bates, D L.]]

Revision as of 19:34, 24 March 2013

Template:STRUCTURE 3qb1

Contents

Interleukin-2 mutant D10

Template:ABSTRACT PUBMED 22446627

Disease

[IL2_HUMAN] Note=A chromosomal aberration involving IL2 is found in a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(4;16)(q26;p13) with involves TNFRSF17.

Function

[IL2_HUMAN] Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells.

About this Structure

3qb1 is a 8 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

See Also

Reference

  • Levin AM, Bates DL, Ring AM, Krieg C, Lin JT, Su L, Moraga I, Raeber ME, Bowman GR, Novick P, Pande VS, Fathman CG, Boyman O, Garcia KC. Exploiting a natural conformational switch to engineer an interleukin-2 'superkine' Nature. 2012 Mar 25. doi: 10.1038/nature10975. PMID:22446627 doi:10.1038/nature10975

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