1oyt

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[[Category: Protein complex]]
[[Category: Protein complex]]
[[Category: Thrombin]]
[[Category: Thrombin]]
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[[Category: Banner, D.W.]]
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[[Category: Banner, D W.]]
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[[Category: Olsen, J.A.]]
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[[Category: Olsen, J A.]]
[[Category: CA]]
[[Category: CA]]
[[Category: FSN]]
[[Category: FSN]]
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[[Category: hydrolase (serine proteinase)]]
[[Category: hydrolase (serine proteinase)]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Feb 15 16:37:30 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:23:23 2008''

Revision as of 12:23, 21 February 2008


1oyt, resolution 1.67Å

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COMPLEX OF RECOMBINANT HUMAN THROMBIN WITH A DESIGNED FLUORINATED INHIBITOR

Disease

Known diseases associated with this structure: Dysprothrombinemia OMIM:[176930], Hyperprothrombinemia OMIM:[176930], Hypoprothrombinemia OMIM:[176930]

About this Structure

1OYT is a Protein complex structure of sequences from Homo sapiens with , and as ligands. Active as Thrombin, with EC number 3.4.21.5 Full crystallographic information is available from OCA.

Reference

A fluorine scan of thrombin inhibitors to map the fluorophilicity/fluorophobicity of an enzyme active site: evidence for C-F...C=O interactions., Olsen JA, Banner DW, Seiler P, Obst Sander U, D'Arcy A, Stihle M, Muller K, Diederich F, Angew Chem Int Ed Engl. 2003 Jun 6;42(22):2507-11. PMID:12800172

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