4aqk

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[[Image:4aqk.jpg|left|200px]]
 
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{{STRUCTURE_4aqk| PDB=4aqk | SCENE= }}
{{STRUCTURE_4aqk| PDB=4aqk | SCENE= }}
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===Inositol 1,3,4,5,6-pentakisphosphate 2-kinase in complex with ADP and IP6===
===Inositol 1,3,4,5,6-pentakisphosphate 2-kinase in complex with ADP and IP6===
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{{ABSTRACT_PUBMED_22684075}}
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==Function==
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[[http://www.uniprot.org/uniprot/IPPK_ARATH IPPK_ARATH]] Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate). Phytate is a regulator of intracellular signaling, a highly abundant animal antinutrient, and a phosphate store in plant seeds. Also phosphorylates Ins(1,3,4,6)P4 and Ins(1,4,5,6)P4 to produce Ins(1,2,3,4,6)P5 and Ins(1,2,4,5,6)P5.<ref>PMID:16107538</ref> <ref>PMID:16223361</ref>
==About this Structure==
==About this Structure==
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[[4aqk]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AQK OCA].
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[[4aqk]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Arath Arath]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AQK OCA].
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[[Category: Arabidopsis thaliana]]
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==Reference==
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<ref group="xtra">PMID:022684075</ref><references group="xtra"/><references/>
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[[Category: Arath]]
[[Category: Inositol-pentakisphosphate 2-kinase]]
[[Category: Inositol-pentakisphosphate 2-kinase]]
[[Category: Banos-Sanz, J I.]]
[[Category: Banos-Sanz, J I.]]

Revision as of 09:02, 5 February 2014

Template:STRUCTURE 4aqk

Contents

Inositol 1,3,4,5,6-pentakisphosphate 2-kinase in complex with ADP and IP6

Template:ABSTRACT PUBMED 22684075

Function

[IPPK_ARATH] Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate). Phytate is a regulator of intracellular signaling, a highly abundant animal antinutrient, and a phosphate store in plant seeds. Also phosphorylates Ins(1,3,4,6)P4 and Ins(1,4,5,6)P4 to produce Ins(1,2,3,4,6)P5 and Ins(1,2,4,5,6)P5.[1] [2]

About this Structure

4aqk is a 1 chain structure with sequence from Arath. Full crystallographic information is available from OCA.

Reference

  • Banos-Sanz JI, Sanz-Aparicio J, Brearley CA, Gonzalez B. Expression, purification, crystallization and preliminary X-ray diffraction analysis of the apo form of InsP5 2-K from Arabidopsis thaliana. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2012 Jun 1;68(Pt 6):701-4. doi:, 10.1107/S1744309112017307. Epub 2012 May 23. PMID:22684075 doi:http://dx.doi.org/10.1107/S1744309112017307
  1. Stevenson-Paulik J, Bastidas RJ, Chiou ST, Frye RA, York JD. Generation of phytate-free seeds in Arabidopsis through disruption of inositol polyphosphate kinases. Proc Natl Acad Sci U S A. 2005 Aug 30;102(35):12612-7. Epub 2005 Aug 17. PMID:16107538 doi:10.1073/pnas.0504172102
  2. Sweetman D, Johnson S, Caddick SE, Hanke DE, Brearley CA. Characterization of an Arabidopsis inositol 1,3,4,5,6-pentakisphosphate 2-kinase (AtIPK1). Biochem J. 2006 Feb 15;394(Pt 1):95-103. PMID:16223361 doi:BJ20051331

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