1qbh
From Proteopedia
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==Overview== | ==Overview== | ||
| - | Members of the inhibitor of apoptosis (IAP) family of proteins are able to | + | Members of the inhibitor of apoptosis (IAP) family of proteins are able to inhibit cell death following viral infection, during development or in cell lines in vitro. All IAP proteins bear one or more baculoviral IAP repeats (BIRs). Here we describe the solution structure of the third BIR domain from the mammalian IAP homolog B (MIHB/c-IAP-1). The BIR domain has a novel fold that is stabilized by zinc tetrahedrally coordinated by one histidine and three cysteine residues. The structure consists of a series of short alpha-helices and turns with the zinc packed in an unusually hydrophobic environment created by residues that are highly conserved among all BIRs. |
==About this Structure== | ==About this Structure== | ||
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[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
| - | [[Category: Day, C | + | [[Category: Day, C L.]] |
| - | [[Category: Hinds, M | + | [[Category: Hinds, M G.]] |
| - | [[Category: Norton, R | + | [[Category: Norton, R S.]] |
| - | [[Category: Vaux, D | + | [[Category: Vaux, D L.]] |
[[Category: ZN]] | [[Category: ZN]] | ||
[[Category: baculoviral iap repeat (bir)]] | [[Category: baculoviral iap repeat (bir)]] | ||
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[[Category: zinc binding domain]] | [[Category: zinc binding domain]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:37:55 2008'' |
Revision as of 12:37, 21 February 2008
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SOLUTION STRUCTURE OF A BACULOVIRAL INHIBITOR OF APOPTOSIS (IAP) REPEAT
Overview
Members of the inhibitor of apoptosis (IAP) family of proteins are able to inhibit cell death following viral infection, during development or in cell lines in vitro. All IAP proteins bear one or more baculoviral IAP repeats (BIRs). Here we describe the solution structure of the third BIR domain from the mammalian IAP homolog B (MIHB/c-IAP-1). The BIR domain has a novel fold that is stabilized by zinc tetrahedrally coordinated by one histidine and three cysteine residues. The structure consists of a series of short alpha-helices and turns with the zinc packed in an unusually hydrophobic environment created by residues that are highly conserved among all BIRs.
About this Structure
1QBH is a Single protein structure of sequence from Homo sapiens with as ligand. Full crystallographic information is available from OCA.
Reference
Solution structure of a baculoviral inhibitor of apoptosis (IAP) repeat., Hinds MG, Norton RS, Vaux DL, Day CL, Nat Struct Biol. 1999 Jul;6(7):648-51. PMID:10404221
Page seeded by OCA on Thu Feb 21 14:37:55 2008
