User:Anthony Davis/Sandbox1 IgE
From Proteopedia
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=IgE Receptor FcϵRI= | =IgE Receptor FcϵRI= | ||
Antibodies are also known as immunoglobulins (Igs). They are part of the Adaptive immune system. When a pathogen invades the body antibodies bind to the pathogen in order to neutralize it and mark it for destruction. The antibodies are grouped into five types IgA, IgD, IgM, IgG, and IgE. They each have specific functions for example IgE binds to allergens and triggers the release of histamine from mast cells and basophils. The basic stucture of an antibody is shown here | Antibodies are also known as immunoglobulins (Igs). They are part of the Adaptive immune system. When a pathogen invades the body antibodies bind to the pathogen in order to neutralize it and mark it for destruction. The antibodies are grouped into five types IgA, IgD, IgM, IgG, and IgE. They each have specific functions for example IgE binds to allergens and triggers the release of histamine from mast cells and basophils. The basic stucture of an antibody is shown here | ||
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[[Image:Antibody.gif]]. | [[Image:Antibody.gif]]. | ||
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| + | The function of the FcϵRI receptor on the surface of mast cells and basophils is to bind to the IgE-antigen complex. [http://en.wikipedia.org/wiki/File:Fc_receptor_schematic.svg]This elicits an immune response which induces these cells to release histamine and initiate an inflammatory response. This is seen in people who suffer from allergies such as Hay fever. Hay fever is an allergic reaction to pollen and some of the symptoms are a runny nose, sneezing, teary eyes. More serious allergic reactions could result in anaphylaxis in which there is restriction of the respiratory pathways and possible cardiac arrest which could result in death. An illustration of of the steps in an allergic reaction is shown in the following link [http://www.niaid.nih.gov/topics/immuneSystem/Pages/disordersImages.aspx#allergicreaction] | ||
Current research involves allergy drugs that will disrupt or interfere with the interaction between IgE and its Fcreceptor. The drug Omalizumab is one such drug that is in use today to help people with allergic asthma. It works by binding to IgE thus interfering with its ability to bind to its receptor and induce an immune response. A recent study has shown an antibody (XmAb7195) to have five times more affinity to IgE than Omalizumab. Research pertaining to IgE will continue to be important in reagards to the treatment of allergic reactions and asthma. | Current research involves allergy drugs that will disrupt or interfere with the interaction between IgE and its Fcreceptor. The drug Omalizumab is one such drug that is in use today to help people with allergic asthma. It works by binding to IgE thus interfering with its ability to bind to its receptor and induce an immune response. A recent study has shown an antibody (XmAb7195) to have five times more affinity to IgE than Omalizumab. Research pertaining to IgE will continue to be important in reagards to the treatment of allergic reactions and asthma. | ||
Revision as of 21:02, 6 May 2012
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Contents |
IgE Receptor FcϵRI
Antibodies are also known as immunoglobulins (Igs). They are part of the Adaptive immune system. When a pathogen invades the body antibodies bind to the pathogen in order to neutralize it and mark it for destruction. The antibodies are grouped into five types IgA, IgD, IgM, IgG, and IgE. They each have specific functions for example IgE binds to allergens and triggers the release of histamine from mast cells and basophils. The basic stucture of an antibody is shown here
Function
The function of the FcϵRI receptor on the surface of mast cells and basophils is to bind to the IgE-antigen complex. [1]This elicits an immune response which induces these cells to release histamine and initiate an inflammatory response. This is seen in people who suffer from allergies such as Hay fever. Hay fever is an allergic reaction to pollen and some of the symptoms are a runny nose, sneezing, teary eyes. More serious allergic reactions could result in anaphylaxis in which there is restriction of the respiratory pathways and possible cardiac arrest which could result in death. An illustration of of the steps in an allergic reaction is shown in the following link [2]
Current research involves allergy drugs that will disrupt or interfere with the interaction between IgE and its Fcreceptor. The drug Omalizumab is one such drug that is in use today to help people with allergic asthma. It works by binding to IgE thus interfering with its ability to bind to its receptor and induce an immune response. A recent study has shown an antibody (XmAb7195) to have five times more affinity to IgE than Omalizumab. Research pertaining to IgE will continue to be important in reagards to the treatment of allergic reactions and asthma.
Structure
The FcϵRI receptor is made up of two (Ig)domains D1 and D2. The domains form a convex shape at the top of the receptor. Another feature of the receptor is the crossover of the A strand from the ABE sheet to the CC'FG sheet.The FG loop and C-C' strands of D2 form part of the binding site for IgE.
References
Garman, Scott C.; Kinet, Jean-Pierre; Jardetzky, Theodore S."Crystal Structure of the Human High-Affinity IgE Receptor" Cell, volume 95 issue 7 pp.951 - 961.
![[1]](http://en.wikipedia.org/wiki/File:Fc_receptor_schematic.svg){kind=link}