Dethiobiotin synthetase
From Proteopedia
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| - | '''Dethiobiotin synthetase''' (DTBS) catalyzes the first ring closure in the biotin synthesis. The reaction transforms 7,8-diaminononanoate (DAN), ATP and CO2 to dethiobiotin, ADP and phosphate. | + | '''Dethiobiotin synthetase''' (DTBS) catalyzes the first ring closure in the biotin synthesis. The reaction transforms 7,8-diaminononanoate (DAN), ATP and CO2 to dethiobiotin (DTB), ADP and phosphate. |
==3D dethiobiotin synthetase== | ==3D dethiobiotin synthetase== | ||
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[[1dah]] - EcDTBS + DAN + Mn + ATP<BR / derivative<br /> | [[1dah]] - EcDTBS + DAN + Mn + ATP<BR / derivative<br /> | ||
| - | [[1bs1]] - EcDTBS + | + | [[1bs1]] - EcDTBS + DTB + Mg + ADP<BR /> |
[[1a82]] - EcDTBS + DAN + Mg + ATP<BR /> | [[1a82]] - EcDTBS + DAN + Mg + ATP<BR /> | ||
| - | [[3fpa]] - MtDTBS + | + | [[3fpa]] - MtDTBS + DTB + Mg + phosphate <br /> |
[[3mle]] - HpDTBS + Mg + phosphate + ADP<BR /> | [[3mle]] - HpDTBS + Mg + phosphate + ADP<BR /> | ||
[[3qy0]] - HpDTBS + Mg + phosphate + GDP<BR /> | [[3qy0]] - HpDTBS + Mg + phosphate + GDP<BR /> | ||
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'''DTBS higher complexes''' | '''DTBS higher complexes''' | ||
| - | [[1dam]] - EcDTBS + | + | [[1dam]] - EcDTBS + DTB + Mg + phosphate + ADP<BR /> |
[[1dak]] - EcDTBS + DAN + mixed anhydride + Mg + phosphate + ADP<BR /> | [[1dak]] - EcDTBS + DAN + mixed anhydride + Mg + phosphate + ADP<BR /> | ||
[[3qxh]] - HpDTBS + aminooctanoic acid + Mg + phosphate + ADP<BR /> | [[3qxh]] - HpDTBS + aminooctanoic acid + Mg + phosphate + ADP<BR /> | ||
[[3qxx]] - HpDTBS + aminooctanoic acid + Mg + phosphate + GTP<BR /> | [[3qxx]] - HpDTBS + aminooctanoic acid + Mg + phosphate + GTP<BR /> | ||
Revision as of 07:34, 8 May 2012
Dethiobiotin synthetase (DTBS) catalyzes the first ring closure in the biotin synthesis. The reaction transforms 7,8-diaminononanoate (DAN), ATP and CO2 to dethiobiotin (DTB), ADP and phosphate.
3D dethiobiotin synthetase
1dbs, 1dts, 1byi]] – EcDTBS – Escherichia coli
2qmo – HpDTBS – Helicobacter pylori
3fgn – MtDTBS – Mycobacterium tuberculosis
3of5 – DTBS – Francicella tularensis
DTBS binary complex
3fmf – MtDTBS + DAN
1dad – EcDTBS + ADP
1dae - EcDTBS + nonanedioate derivative
3fmi – MtDTBS + aminopelargonic acid
1dai - EcDTBS + DAN
DTBS ternary complex
3qxc - HpDTBS + Mg + ATP
1daf - EcDTBS + DAN + ADP
1dag - EcDTBS + DAN + ATP derivative
3qxj - HpDTBS + Mg + ATP
3qxs - HpDTBS + Mg + phosphoaminophosphonic acid
DTBS quaternary complex
1dah - EcDTBS + DAN + Mn + ATP<BR / derivative
1bs1 - EcDTBS + DTB + Mg + ADP
1a82 - EcDTBS + DAN + Mg + ATP
3fpa - MtDTBS + DTB + Mg + phosphate
3mle - HpDTBS + Mg + phosphate + ADP
3qy0 - HpDTBS + Mg + phosphate + GDP
DTBS higher complexes
1dam - EcDTBS + DTB + Mg + phosphate + ADP
1dak - EcDTBS + DAN + mixed anhydride + Mg + phosphate + ADP
3qxh - HpDTBS + aminooctanoic acid + Mg + phosphate + ADP
3qxx - HpDTBS + aminooctanoic acid + Mg + phosphate + GTP
