3vkb
From Proteopedia
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| - | [[ | + | ==Crystal structure of MoeO5 soaked with FsPP overnight== |
| + | <StructureSection load='3vkb' size='340' side='right' caption='[[3vkb]], [[Resolution|resolution]] 1.80Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[3vkb]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptomyces_ghanaensis Streptomyces ghanaensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VKB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3VKB FirstGlance]. <br> | ||
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=FPS:S-[(2E,6E)-3,7,11-TRIMETHYLDODECA-2,6,10-TRIENYL]+TRIHYDROGEN+THIODIPHOSPHATE'>FPS</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=POP:PYROPHOSPHATE+2-'>POP</scene></td></tr> | ||
| + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3vk5|3vk5]], [[3vka|3vka]], [[3vkc|3vkc]], [[3vkd|3vkd]]</td></tr> | ||
| + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">moeO5 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=35758 Streptomyces ghanaensis])</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3vkb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3vkb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3vkb RCSB], [http://www.ebi.ac.uk/pdbsum/3vkb PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | New antibiotics are needed because of the increasing occurrence of multidrug resistance, as seen in Staphylococcus aureus (MRSA). The initiating step of the biosynthesis of the next-generation drug moenomycin is catalyzed by MoeO5, which is a prenyltransferase with triose-phosphate-isomerase barrel structure as was shown by E. Oldfield, R.-T. Guo, and co-workers in their Communication (DOI:10.1002/anie.201108002). The transferred farnesyl group undergoes a trans-to-cis conversion in its first double bond. | ||
| - | + | Insights into the Mechanism of the Antibiotic-Synthesizing Enzyme MoeO5 from Crystal Structures of Different Complexes.,Ren F, Ko TP, Feng X, Huang CH, Chan HC, Hu Y, Wang K, Ma Y, Liang PH, Wang AH, Oldfield E, Guo RT Angew Chem Int Ed Engl. 2012 Mar 20. doi: 10.1002/anie.201201339. PMID:22434765<ref>PMID:22434765</ref> | |
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| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | + | </div> | |
| - | + | == References == | |
| - | + | <references/> | |
| - | + | __TOC__ | |
| - | + | </StructureSection> | |
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| - | == | + | |
| - | < | + | |
[[Category: Streptomyces ghanaensis]] | [[Category: Streptomyces ghanaensis]] | ||
| - | [[Category: Guo, R T | + | [[Category: Guo, R T]] |
| - | [[Category: Huang, C H | + | [[Category: Huang, C H]] |
| - | [[Category: Ko, T P | + | [[Category: Ko, T P]] |
| - | [[Category: Ren, F | + | [[Category: Ren, F]] |
[[Category: Tim barrel]] | [[Category: Tim barrel]] | ||
[[Category: Transferase]] | [[Category: Transferase]] | ||
Revision as of 09:15, 4 January 2015
Crystal structure of MoeO5 soaked with FsPP overnight
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