1suv
From Proteopedia
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==Overview== | ==Overview== | ||
| - | Iron, insoluble as free Fe(3+) and toxic as free Fe(2+), is distributed | + | Iron, insoluble as free Fe(3+) and toxic as free Fe(2+), is distributed through the body as Fe(3+) bound to transferrin (Tf) for delivery to cells by endocytosis of its complex with transferrin receptor (TfR). Although much is understood of the transferrin endocytotic cycle, little has been uncovered of the molecular details underlying the formation of the receptor-transferrin complex. Using cryo-electron microscopy, we have produced a density map of the TfR-Tf complex at subnanometer resolution. An atomic model, obtained by fitting crystal structures of diferric Tf and the receptor ectodomain into the map, shows that the Tf N-lobe is sandwiched between the membrane and the TfR ectodomain and that the C-lobe abuts the receptor helical domain. When Tf binds receptor, its N-lobe moves by about 9 A with respect to its C-lobe. The structure of TfR-Tf complex helps account for known differences in the iron-release properties of free and receptor bound Tf. |
==Disease== | ==Disease== | ||
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[[Category: Aisen, P.]] | [[Category: Aisen, P.]] | ||
[[Category: Cheng, Y.]] | [[Category: Cheng, Y.]] | ||
| - | [[Category: Harrison, S | + | [[Category: Harrison, S C.]] |
[[Category: Walz, T.]] | [[Category: Walz, T.]] | ||
[[Category: Zak, O.]] | [[Category: Zak, O.]] | ||
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[[Category: protein complex]] | [[Category: protein complex]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 15:05:24 2008'' |
Revision as of 13:05, 21 February 2008
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Structure of Human Transferrin Receptor-Transferrin Complex
Contents |
Overview
Iron, insoluble as free Fe(3+) and toxic as free Fe(2+), is distributed through the body as Fe(3+) bound to transferrin (Tf) for delivery to cells by endocytosis of its complex with transferrin receptor (TfR). Although much is understood of the transferrin endocytotic cycle, little has been uncovered of the molecular details underlying the formation of the receptor-transferrin complex. Using cryo-electron microscopy, we have produced a density map of the TfR-Tf complex at subnanometer resolution. An atomic model, obtained by fitting crystal structures of diferric Tf and the receptor ectodomain into the map, shows that the Tf N-lobe is sandwiched between the membrane and the TfR ectodomain and that the C-lobe abuts the receptor helical domain. When Tf binds receptor, its N-lobe moves by about 9 A with respect to its C-lobe. The structure of TfR-Tf complex helps account for known differences in the iron-release properties of free and receptor bound Tf.
Disease
Known diseases associated with this structure: Atransferrinemia OMIM:[190000], Iron deficiency anemia, susceptibility to OMIM:[190000]
About this Structure
1SUV is a Protein complex structure of sequences from Homo sapiens with and as ligands. Full crystallographic information is available from OCA.
Reference
Structure of the human transferrin receptor-transferrin complex., Cheng Y, Zak O, Aisen P, Harrison SC, Walz T, Cell. 2004 Feb 20;116(4):565-76. PMID:14980223
Page seeded by OCA on Thu Feb 21 15:05:24 2008
Categories: Homo sapiens | Protein complex | Aisen, P. | Cheng, Y. | Harrison, S C. | Walz, T. | Zak, O. | CO3 | FE
