4dk5
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
| - | [[Image:4dk5. | + | [[Image:4dk5.png|left|200px]] |
| - | <!-- | ||
| - | The line below this paragraph, containing "STRUCTURE_4dk5", creates the "Structure Box" on the page. | ||
| - | You may change the PDB parameter (which sets the PDB file loaded into the applet) | ||
| - | or the SCENE parameter (which sets the initial scene displayed when the page is loaded), | ||
| - | or leave the SCENE parameter empty for the default display. | ||
| - | --> | ||
{{STRUCTURE_4dk5| PDB=4dk5 | SCENE= }} | {{STRUCTURE_4dk5| PDB=4dk5 | SCENE= }} | ||
===Crystal structure of human PI3K-gamma in complex with a pyridyl-triazine inhibitor=== | ===Crystal structure of human PI3K-gamma in complex with a pyridyl-triazine inhibitor=== | ||
| - | |||
| - | <!-- | ||
| - | The line below this paragraph, {{ABSTRACT_PUBMED_22548365}}, adds the Publication Abstract to the page | ||
| - | (as it appears on PubMed at http://www.pubmed.gov), where 22548365 is the PubMed ID number. | ||
| - | --> | ||
{{ABSTRACT_PUBMED_22548365}} | {{ABSTRACT_PUBMED_22548365}} | ||
Revision as of 05:00, 1 August 2012
Crystal structure of human PI3K-gamma in complex with a pyridyl-triazine inhibitor
Template:ABSTRACT PUBMED 22548365
About this Structure
4dk5 is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Smith AL, D'Angelo ND, Bo YY, Booker SK, Cee VJ, Herberich B, Hong FT, Jackson CL, Lanman BA, Liu L, Nishimura N, Pettus LH, Reed AB, Tadesse S, Tamayo NA, Wurz RP, Yang K, Andrews KL, Whittington DA, McCarter JD, San Miguel T, Zalameda L, Jiang J, Subramanian R, Mullady EL, Caenepeel S, Freeman DJ, Wang L, Zhang N, Wu T, Hughes PE, Norman MH. Structure-Based Design of a Novel Series of Potent, Selective Inhibitors of the Class I Phosphatidylinositol 3-Kinases. J Med Chem. 2012 May 1. PMID:22548365 doi:10.1021/jm300184s
