4aj5

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[[Image:4aj5.jpg|left|200px]]
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==Crystal structure of the Ska core complex==
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<StructureSection load='4aj5' size='340' side='right' caption='[[4aj5]], [[Resolution|resolution]] 3.32&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4aj5]] is a 30 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AJ5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4AJ5 FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4aj5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4aj5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4aj5 RCSB], [http://www.ebi.ac.uk/pdbsum/4aj5 PDBsum]</span></td></tr>
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<table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The Ska complex is an essential mitotic component required for accurate cell division in human cells. It is composed of three subunits that function together to establish stable kinetochore-microtubule interactions in concert with the Ndc80 network. We show that the structure of the Ska core complex is a W-shaped dimer of coiled coils, formed by intertwined interactions between Ska1, Ska2, and Ska3. The C-terminal domains of Ska1 and Ska3 protrude at each end of the homodimer, bind microtubules in vitro when connected to the central core, and are essential in vivo. Mutations disrupting the central coiled coil or the dimerization interface result in chromosome congression failure followed by cell death. The Ska complex is thus endowed with bipartite and cooperative tubulin-binding properties at the ends of a 350 A-long molecule. We discuss how this symmetric architecture might complement and stabilize the Ndc80-microtubule attachments with analogies to the yeast Dam1/DASH complex.
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Structural and functional organization of the ska complex, a key component of the kinetochore-microtubule interface.,Jeyaprakash AA, Santamaria A, Jayachandran U, Chan YW, Benda C, Nigg EA, Conti E Mol Cell. 2012 May 11;46(3):274-86. Epub 2012 Apr 5. PMID:22483620<ref>PMID:22483620</ref>
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The line below this paragraph, containing "STRUCTURE_4aj5", creates the "Structure Box" on the page.
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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or leave the SCENE parameter empty for the default display.
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{{STRUCTURE_4aj5| PDB=4aj5 | SCENE= }}
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===Crystal structure of the Ska core complex===
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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== References ==
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<references/>
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The line below this paragraph, {{ABSTRACT_PUBMED_22483620}}, adds the Publication Abstract to the page
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 22483620 is the PubMed ID number.
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</StructureSection>
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{{ABSTRACT_PUBMED_22483620}}
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==About this Structure==
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[[4aj5]] is a 30 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AJ5 OCA].
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==Reference==
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<ref group="xtra">PMID:022483620</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Benda, C.]]
[[Category: Benda, C.]]

Revision as of 07:38, 5 June 2014

Crystal structure of the Ska core complex

4aj5, resolution 3.32Å

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