4aux

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[[Image:4aux.jpg|left|200px]]
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==Tet repressor class D in complex with 9-nitrotetracycline==
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<StructureSection load='4aux' size='340' side='right' caption='[[4aux]], [[Resolution|resolution]] 2.25&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4aux]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AUX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4AUX FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=XTC:(4S,4AS,5AR,12AS)-4-(DIMETHYLAMINO)-3,10,12,12A-TETRAHYDROXY-9-NITRO-1,11-DIOXO-1,4,4A,5,5A,6,11,12A-OCTAHYDROTETRACENE-2-CARBOXAMIDE'>XTC</scene><br>
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<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1a6i|1a6i]], [[1bj0|1bj0]], [[1bjy|1bjy]], [[1bjz|1bjz]], [[1du7|1du7]], [[1ork|1ork]], [[1qpi|1qpi]], [[2tct|2tct]], [[2trt|2trt]], [[2vke|2vke]], [[2vkv|2vkv]], [[2x6o|2x6o]], [[2x9d|2x9d]], [[2xb5|2xb5]], [[2xgc|2xgc]], [[2xgd|2xgd]], [[2xge|2xge]], [[2xps|2xps]], [[2xpt|2xpt]], [[2xpu|2xpu]], [[2xpv|2xpv]], [[2xpw|2xpw]], [[2xrl|2xrl]], [[3zqf|3zqf]], [[3zqg|3zqg]], [[3zqh|3zqh]], [[3zqi|3zqi]], [[4abz|4abz]]</td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4aux FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4aux OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4aux RCSB], [http://www.ebi.ac.uk/pdbsum/4aux PDBsum]</span></td></tr>
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<table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The most frequently occurring resistance of Gram-negative bacteria against tetracyclines is triggered by drug recognition of the Tet repressor. This causes dissociation of the repressor-operator DNA complex and enables expression of the resistance protein TetA, which is responsible for active efflux of tetracycline. The 2.5 angstrom resolution crystal structure of the homodimeric Tet repressor complexed with tetracycline-magnesium reveals detailed drug recognition. The orientation of the operator-binding helix-turn-helix motifs of the repressor is inverted in comparison with other DNA binding proteins. The repressor-drug complex is unable to interact with DNA because the separation of the DNA binding motifs is 5 angstroms wider than usually observed.
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Structure of the Tet repressor-tetracycline complex and regulation of antibiotic resistance.,Hinrichs W, Kisker C, Duvel M, Muller A, Tovar K, Hillen W, Saenger W Science. 1994 Apr 15;264(5157):418-20. PMID:8153629<ref>PMID:8153629</ref>
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The line below this paragraph, containing "STRUCTURE_4aux", creates the "Structure Box" on the page.
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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or leave the SCENE parameter empty for the default display.
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{{STRUCTURE_4aux| PDB=4aux | SCENE= }}
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===Tet repressor class D in complex with 9-nitrotetracycline===
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
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</div>
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==See Also==
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*[[Tetracycline repressor protein|Tetracycline repressor protein]]
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The line below this paragraph, {{ABSTRACT_PUBMED_8153629}}, adds the Publication Abstract to the page
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== References ==
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(as it appears on PubMed at http://www.pubmed.gov), where 8153629 is the PubMed ID number.
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<references/>
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__TOC__
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{{ABSTRACT_PUBMED_8153629}}
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</StructureSection>
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==About this Structure==
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[[4aux]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AUX OCA].
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==Reference==
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<ref group="xtra">PMID:008153629</ref><references group="xtra"/>
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[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
[[Category: Hinrichs, W.]]
[[Category: Hinrichs, W.]]

Revision as of 07:21, 5 June 2014

Tet repressor class D in complex with 9-nitrotetracycline

4aux, resolution 2.25Å

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