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1xuo

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==Overview==
==Overview==
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1,4-Diazepane-2,5-diones (2) are found to be a new class of potent LFA-1, inhibitors. The synthesis, structure, and biological evaluation of these, 1,4-diazepine-2,5-diones and related derivatives are described.
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1,4-Diazepane-2,5-diones (2) are found to be a new class of potent LFA-1 inhibitors. The synthesis, structure, and biological evaluation of these 1,4-diazepine-2,5-diones and related derivatives are described.
==About this Structure==
==About this Structure==
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[[Category: integrin]]
[[Category: integrin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Feb 15 17:10:34 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 15:58:59 2008''

Revision as of 13:59, 21 February 2008

Image:1xuo.jpg

1xuo, resolution 1.80Å

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X-ray structure of LFA-1 I-domain bound to a 1,4-diazepane-2,5-dione inhibitor at 1.8A resolution

Overview

1,4-Diazepane-2,5-diones (2) are found to be a new class of potent LFA-1 inhibitors. The synthesis, structure, and biological evaluation of these 1,4-diazepine-2,5-diones and related derivatives are described.

About this Structure

1XUO is a Single protein structure of sequence from Homo sapiens with and as ligands. Full crystallographic information is available from OCA.

Reference

1,4-Diazepane-2,5-diones as novel inhibitors of LFA-1., Wattanasin S, Kallen J, Myers S, Guo Q, Sabio M, Ehrhardt C, Albert R, Hommel U, Weckbecker G, Welzenbach K, Weitz-Schmidt G, Bioorg Med Chem Lett. 2005 Feb 15;15(4):1217-20. PMID:15686945

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