Aspartate-semialdehyde dehydrogenase
From Proteopedia
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== 3D Structures of Aspartate-semialdehyde dehydrogenase == | == 3D Structures of Aspartate-semialdehyde dehydrogenase == | ||
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[[2qz9]], [[1mc4]] – VcASADH II – ''Vibrio cholerae''<br /> | [[2qz9]], [[1mc4]] – VcASADH II – ''Vibrio cholerae''<br /> | ||
[[2yv3]] – ASADH – ''Thermus thermiphilus''<br /> | [[2yv3]] – ASADH – ''Thermus thermiphilus''<br /> | ||
[[1t4d]], [[1t4b]], [[1brm]] - EcASADH β - ''Escherichia coli''<br /> | [[1t4d]], [[1t4b]], [[1brm]] - EcASADH β - ''Escherichia coli''<br /> | ||
| - | [[1pu2]], [[1oza]] - HiASADH (mutant) – ''Haemophilus influenzae''<br /> | + | [[1pu2]], [[1oza]], [[1pr3]], [[1ps8]] - HiASADH (mutant) – ''Haemophilus influenzae''<br /> |
[[1nwc]] – HiASADH<br /> | [[1nwc]] – HiASADH<br /> | ||
[[1nwh]] – HiASADH reaction intermediate<br /> | [[1nwh]] – HiASADH reaction intermediate<br /> | ||
| + | [[2gyy]] – SpASADH – ''Streptococcus pneumonia''<br /> | ||
| + | [[3uw3]] - ASADH – ''Burkholderia thailandensis'' | ||
===ASADH binary complex=== | ===ASADH binary complex=== | ||
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[[1tb4]] - HiASADH + IO4<br /> | [[1tb4]] - HiASADH + IO4<br /> | ||
[[1q2x]] - HiASADH (mutant) + ASA<br /> | [[1q2x]] - HiASADH (mutant) + ASA<br /> | ||
| + | [[2gz1]] - SpASADH + NADP<br /> | ||
| + | [[2gz2]] - SpASADH + ADP<br /> | ||
| + | [[3pyl]] - SpASADH + diaminopropionate<br /> | ||
| + | [[3q0e]] - VcASADH + cysteine sulfoxide<br /> | ||
| + | [[3q1l]] - SpASADH + cysteamine | ||
===ASADH ternary complex=== | ===ASADH ternary complex=== | ||
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[[1gl3]] - EcASADH β + NADP + substrate analog<br /> | [[1gl3]] - EcASADH β + NADP + substrate analog<br /> | ||
[[1mb4]] - VcASADH + NADP + substrate analog<br /> | [[1mb4]] - VcASADH + NADP + substrate analog<br /> | ||
| + | [[3pzr]] - VcASADH + NADP + carbamoyl-cysteine <br /> | ||
| + | [[2gz3]] - SpASADH + NADP + ASA<br /> | ||
| + | [[3pwk]], [[3pws]] - SpASADH + NADP + aminoadipate<br /> | ||
| + | [[3pyx]] - SpASADH + NADP + aminoterephthalate <br /> | ||
| + | [[3pzb]] - SpASADH + NADP + diaminopropionate<br /> | ||
| + | [[3q11]] - SpASADH + NADP + inhibitor | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Revision as of 08:21, 31 May 2012
Aspartate-semialdehyde dehydrogenase (ASADH) is an enzyme which is part of the biosynthesis of amino acids. It catalyzes the conversion of L-aspartate 4-semialdehyde (ASA) + phosphate + NADP to L-4-aspartyl phosphate + NADPH + H+. The images at the left and at the right correspond to one representative ASADH, i.e. the crystal structure of Aspartate-semialdehyde dehydrogenase from Vibrio cholerae (1mc4).
Contents |
3D Structures of Aspartate-semialdehyde dehydrogenase
Update May 2012
2qz9, 1mc4 – VcASADH II – Vibrio cholerae
2yv3 – ASADH – Thermus thermiphilus
1t4d, 1t4b, 1brm - EcASADH β - Escherichia coli
1pu2, 1oza, 1pr3, 1ps8 - HiASADH (mutant) – Haemophilus influenzae
1nwc – HiASADH
1nwh – HiASADH reaction intermediate
2gyy – SpASADH – Streptococcus pneumonia
3uw3 - ASADH – Burkholderia thailandensis
ASADH binary complex
2r00 - VcASADH II + ASA
3llg – ASADH + glycerot + Pi – Mycobacterium tuberculosis
3hsk – ASADH + NADP – Candida albicans
1ys4 - ASADH + NADP – Methanocaldococcus jannaschii
1nx6 - HiASADH reaction intermediate +Pi
1ta4 - HiASADH + As
1tb4 - HiASADH + IO4
1q2x - HiASADH (mutant) + ASA
2gz1 - SpASADH + NADP
2gz2 - SpASADH + ADP
3pyl - SpASADH + diaminopropionate
3q0e - VcASADH + cysteine sulfoxide
3q1l - SpASADH + cysteamine
ASADH ternary complex
1pqu - HiASADH (mutant) + NADP + cacodylate + substrate analog
1pqp - HiASADH (mutant) + ASA + Pi
1gl3 - EcASADH β + NADP + substrate analog
1mb4 - VcASADH + NADP + substrate analog
3pzr - VcASADH + NADP + carbamoyl-cysteine
2gz3 - SpASADH + NADP + ASA
3pwk, 3pws - SpASADH + NADP + aminoadipate
3pyx - SpASADH + NADP + aminoterephthalate
3pzb - SpASADH + NADP + diaminopropionate
3q11 - SpASADH + NADP + inhibitor
