2e6a

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[[Image:2e6a.png|left|200px]]
 
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{{STRUCTURE_2e6a| PDB=2e6a | SCENE= }}
{{STRUCTURE_2e6a| PDB=2e6a | SCENE= }}
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===Crystal structure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with orotate===
===Crystal structure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with orotate===
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==Function==
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[[http://www.uniprot.org/uniprot/Q4D3W2_TRYCR Q4D3W2_TRYCR]] Catalyzes the conversion of dihydroorotate to orotate with fumarate as the electron acceptor. Molecular oxygen can replace fumarate in vitro.
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{{ABSTRACT_PUBMED_018808149}}
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==About this Structure==
==About this Structure==
[[2e6a]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Trypanosoma_cruzi Trypanosoma cruzi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E6A OCA].
[[2e6a]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Trypanosoma_cruzi Trypanosoma cruzi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E6A OCA].
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==See Also==
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*[[Dihydroorotate dehydrogenase|Dihydroorotate dehydrogenase]]
==Reference==
==Reference==
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<ref group="xtra">PMID:018808149</ref><references group="xtra"/>
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<ref group="xtra">PMID:018808149</ref><references group="xtra"/><references/>
[[Category: Dihydroorotate oxidase]]
[[Category: Dihydroorotate oxidase]]
[[Category: Trypanosoma cruzi]]
[[Category: Trypanosoma cruzi]]

Revision as of 08:27, 23 April 2014

Template:STRUCTURE 2e6a

Contents

Crystal structure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with orotate

Function

[Q4D3W2_TRYCR] Catalyzes the conversion of dihydroorotate to orotate with fumarate as the electron acceptor. Molecular oxygen can replace fumarate in vitro.

About this Structure

2e6a is a 2 chain structure with sequence from Trypanosoma cruzi. Full crystallographic information is available from OCA.

See Also

Reference

  • Inaoka DK, Sakamoto K, Shimizu H, Shiba T, Kurisu G, Nara T, Aoki T, Kita K, Harada S. Structures of Trypanosoma cruzi dihydroorotate dehydrogenase complexed with substrates and products: atomic resolution insights into mechanisms of dihydroorotate oxidation and fumarate reduction. Biochemistry. 2008 Oct 14;47(41):10881-91. Epub 2008 Sep 23. PMID:18808149 doi:10.1021/bi800413r

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