2bfo

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[[Image:2bfo.png|left|200px]]
 
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{{STRUCTURE_2bfo| PDB=2bfo | SCENE= }}
{{STRUCTURE_2bfo| PDB=2bfo | SCENE= }}
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===LEISHMANIA MAJOR PTERIDINE REDUCTASE 1 IN COMPLEX WITH NADPH===
===LEISHMANIA MAJOR PTERIDINE REDUCTASE 1 IN COMPLEX WITH NADPH===
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{{ABSTRACT_PUBMED_16055151}}
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==Function==
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[[http://www.uniprot.org/uniprot/PTR1_LEIMA PTR1_LEIMA]] Exhibits a NADPH-dependent biopterin reductase activity. Has good activity with folate and significant activity with dihydrofolate and dihydrobiopterin, but not with quinonoid dihydrobiopterin. Confers resistance to methotrexate (MTX).<ref>PMID:7972081</ref>
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{{ABSTRACT_PUBMED_16055151}}
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==About this Structure==
==About this Structure==
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==See Also==
==See Also==
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*[[User:Matt Whelihan|User:Matt Whelihan]]
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*[[Pteridine reductase|Pteridine reductase]]
==Reference==
==Reference==
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<ref group="xtra">PMID:016055151</ref><references group="xtra"/>
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<ref group="xtra">PMID:016055151</ref><references group="xtra"/><references/>
[[Category: Leishmania major]]
[[Category: Leishmania major]]
[[Category: Pteridine reductase]]
[[Category: Pteridine reductase]]

Revision as of 08:37, 23 April 2014

Template:STRUCTURE 2bfo

Contents

LEISHMANIA MAJOR PTERIDINE REDUCTASE 1 IN COMPLEX WITH NADPH

Template:ABSTRACT PUBMED 16055151

Function

[PTR1_LEIMA] Exhibits a NADPH-dependent biopterin reductase activity. Has good activity with folate and significant activity with dihydrofolate and dihydrobiopterin, but not with quinonoid dihydrobiopterin. Confers resistance to methotrexate (MTX).[1]

About this Structure

2bfo is a 4 chain structure with sequence from Leishmania major. Full crystallographic information is available from OCA.

See Also

Reference

  • Schuttelkopf AW, Hardy LW, Beverley SM, Hunter WN. Structures of Leishmania major pteridine reductase complexes reveal the active site features important for ligand binding and to guide inhibitor design. J Mol Biol. 2005 Sep 9;352(1):105-16. PMID:16055151 doi:http://dx.doi.org/10.1016/j.jmb.2005.06.076
  1. ↑ Bello AR, Nare B, Freedman D, Hardy L, Beverley SM. PTR1: a reductase mediating salvage of oxidized pteridines and methotrexate resistance in the protozoan parasite Leishmania major. Proc Natl Acad Sci U S A. 1994 Nov 22;91(24):11442-6. PMID:7972081

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OCA

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