2wd8
From Proteopedia
(Difference between revisions)
m (Protected "2wd8" [edit=sysop:move=sysop]) |
|||
| Line 1: | Line 1: | ||
[[Image:2wd8.png|left|200px]] | [[Image:2wd8.png|left|200px]] | ||
| - | <!-- | ||
| - | The line below this paragraph, containing "STRUCTURE_2wd8", creates the "Structure Box" on the page. | ||
| - | You may change the PDB parameter (which sets the PDB file loaded into the applet) | ||
| - | or the SCENE parameter (which sets the initial scene displayed when the page is loaded), | ||
| - | or leave the SCENE parameter empty for the default display. | ||
| - | --> | ||
{{STRUCTURE_2wd8| PDB=2wd8 | SCENE= }} | {{STRUCTURE_2wd8| PDB=2wd8 | SCENE= }} | ||
===PTERIDINE REDUCTASE 1 (PTR1) FROM TRYPANOSOMA BRUCEI IN COMPLEX WITH NADP AND DDD00071204=== | ===PTERIDINE REDUCTASE 1 (PTR1) FROM TRYPANOSOMA BRUCEI IN COMPLEX WITH NADP AND DDD00071204=== | ||
| - | |||
| - | <!-- | ||
| - | The line below this paragraph, {{ABSTRACT_PUBMED_19527033}}, adds the Publication Abstract to the page | ||
| - | (as it appears on PubMed at http://www.pubmed.gov), where 19527033 is the PubMed ID number. | ||
| - | --> | ||
{{ABSTRACT_PUBMED_19527033}} | {{ABSTRACT_PUBMED_19527033}} | ||
Revision as of 12:46, 30 January 2013
PTERIDINE REDUCTASE 1 (PTR1) FROM TRYPANOSOMA BRUCEI IN COMPLEX WITH NADP AND DDD00071204
Template:ABSTRACT PUBMED 19527033
About this Structure
2wd8 is a 4 chain structure with sequence from Trypanosoma brucei brucei. Full crystallographic information is available from OCA.
Reference
- Mpamhanga CP, Spinks D, Tulloch LB, Shanks EJ, Robinson DA, Collie IT, Fairlamb AH, Wyatt PG, Frearson JA, Hunter WN, Gilbert IH, Brenk R. One Scaffold, Three Binding Modes: Novel and Selective Pteridine Reductase 1 Inhibitors Derived from Fragment Hits Discovered by Virtual Screening. J Med Chem. 2009 Jun 15. PMID:19527033 doi:10.1021/jm900414x
- Dawson A, Gibellini F, Sienkiewicz N, Tulloch LB, Fyfe PK, McLuskey K, Fairlamb AH, Hunter WN. Structure and reactivity of Trypanosoma brucei pteridine reductase: inhibition by the archetypal antifolate methotrexate. Mol Microbiol. 2006 Sep;61(6):1457-68. PMID:16968221 doi:10.1111/j.1365-2958.2006.05332.x
