3c7q
From Proteopedia
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===Structure of VEGFR2 kinase domain in complex with BIBF1120=== | ===Structure of VEGFR2 kinase domain in complex with BIBF1120=== | ||
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Revision as of 15:35, 27 July 2012
Contents |
Structure of VEGFR2 kinase domain in complex with BIBF1120
Template:ABSTRACT PUBMED 18559524
About this Structure
3c7q is a 1 chain structure of Vascular Endothelial Growth Factor Receptor with sequence from Homo sapiens. Full crystallographic information is available from OCA.
See Also
Reference
- Hilberg F, Roth GJ, Krssak M, Kautschitsch S, Sommergruber W, Tontsch-Grunt U, Garin-Chesa P, Bader G, Zoephel A, Quant J, Heckel A, Rettig WJ. BIBF 1120: triple angiokinase inhibitor with sustained receptor blockade and good antitumor efficacy. Cancer Res. 2008 Jun 15;68(12):4774-82. PMID:18559524 doi:68/12/4774
- Roth GJ, Heckel A, Colbatzky F, Handschuh S, Kley J, Lehmann-Lintz T, Lotz R, Tontsch-Grunt U, Walter R, Hilberg F. Design, synthesis, and evaluation of indolinones as triple angiokinase inhibitors and the discovery of a highly specific 6-methoxycarbonyl-substituted indolinone (BIBF 1120). J Med Chem. 2009 Jul 23;52(14):4466-80. PMID:19522465 doi:10.1021/jm900431g
Categories: Homo sapiens | Receptor protein-tyrosine kinase | Bader, G. | Garin-Chesa, P. | Heckel, A. | Hilberg, F. | Kautschitsch, S. | Krssak, M. | Quant, J. | Rettig, W J. | Roth, G J. | Sommergruber, W. | Tontsch-Grunt, U. | Zoephel, A. | Alpha beta | Angiogenesis | Atp-binding | Developmental protein | Differentiation | Glycoprotein | Host-virus interaction | Immunoglobulin domain | Kinase | Membrane | Nucleotide-binding | Phosphoprotein | Receptor | Transferase | Transmembrane | Tyrosine-protein kinase
