3hod
From Proteopedia
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[[Image:3hod.png|left|200px]] | [[Image:3hod.png|left|200px]] | ||
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{{STRUCTURE_3hod| PDB=3hod | SCENE= }} | {{STRUCTURE_3hod| PDB=3hod | SCENE= }} | ||
===Crystal structure of the PPARgamma-LBD complexed with a new aryloxy-3phenylpropanoic acid=== | ===Crystal structure of the PPARgamma-LBD complexed with a new aryloxy-3phenylpropanoic acid=== | ||
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Revision as of 16:04, 27 July 2012
Contents |
Crystal structure of the PPARgamma-LBD complexed with a new aryloxy-3phenylpropanoic acid
Template:ABSTRACT PUBMED 19775169
About this Structure
3hod is a 2 chain structure of Peroxisome Proliferator-Activated Receptors with sequence from Homo sapiens. Full crystallographic information is available from OCA.
See Also
Reference
- Fracchiolla G, Laghezza A, Piemontese L, Tortorella P, Mazza F, Montanari R, Pochetti G, Lavecchia A, Novellino E, Pierno S, Conte Camerino D, Loiodice F. New 2-aryloxy-3-phenyl-propanoic acids as peroxisome proliferator-activated receptors alpha/gamma dual agonists with improved potency and reduced adverse effects on skeletal muscle function. J Med Chem. 2009 Oct 22;52(20):6382-93. PMID:19775169 doi:10.1021/jm900941b
- Montanari R, Saccoccia F, Scotti E, Crestani M, Godio C, Gilardi F, Loiodice F, Fracchiolla G, Laghezza A, Tortorella P, Lavecchia A, Novellino E, Mazza F, Aschi M, Pochetti G. Crystal structure of the peroxisome proliferator-activated receptor gamma (PPARgamma) ligand binding domain complexed with a novel partial agonist: a new region of the hydrophobic pocket could be exploited for drug design. J Med Chem. 2008 Dec 25;51(24):7768-76. PMID:19053776 doi:10.1021/jm800733h
Categories: Homo sapiens | Fracchiolla, G. | Laghezza, A. | Lavecchia, A. | Loiodice, F. | Mazza, F. | Montanari, R. | Novellino, E. | Pochetti, G. | Activator | Bundle of alpha-helice | Diabetes mellitus | Disease mutation | Dna-binding | Metal-binding | Nucleus | Obesity | Phosphoprotein | Receptor | Small four-stranded beta-sheet | Transcription | Transcription regulation | Zinc-finger
