Hyaluronidase

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{{STRUCTURE_1c82| PDB=1c82 | SIZE=400| SCENE= |right|CAPTION=Hyaluronidase complex with hyaluronic acid disaccharide and dimethylarsinate, [[1c82]] }}
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<StructureSection load="1c82" size="400" color="" frame="true" spin="on" Scene= align="right" caption='Hyaluronidase complex with hyaluronic acid disaccharide and dimethylarsinate, [[1c82]]' >
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'''Hyaluronidase''' (HU) hydrolyzes complex carbohydrates such as hyaluronan which is part of the extracellular matrix. The hydrolysis increases tissue permeability. HU is used in medicine to speed drug delivery. Hyaluronic acid (HUA) is a popular dermal filler material.
'''Hyaluronidase''' (HU) hydrolyzes complex carbohydrates such as hyaluronan which is part of the extracellular matrix. The hydrolysis increases tissue permeability. HU is used in medicine to speed drug delivery. Hyaluronic acid (HUA) is a popular dermal filler material.
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{|
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|-valign="top"
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|[[Image:hya_xdt_100906.jpeg|left|thumb|'''Superposition of the EGF-like domain of hyaluronidase-1 (yellow) and the heparin-binding EGF-like growth factor (light blue)'''. The three disulfide bonds of the EGF domains (highlighted red) exhibit the same pattern in the primary structure and are located in similar positions in the 3D structure. |150px]]
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|[[Image:Hyal reaction.jpg|thumb|right|'''Hyaluronidase cleaves the β1,4-glycosidic bond of the glycosaminoglycan hyaluronan''' |400px]]
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|}
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==3D structures of hyaluronidase==
==3D structures of hyaluronidase==
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[[2yvv]] - SpyHU + lactose<br />
[[2yvv]] - SpyHU + lactose<br />
[[3eka]] - SpyHU + ascorbate <br />
[[3eka]] - SpyHU + ascorbate <br />
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==Reference==
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Structure of human hyaluronidase-1, a hyaluronan hydrolyzing enzyme involved in tumor growth and angiogenesis., Chao KL, Muthukumar L, Herzberg O, Biochemistry. 2007 Jun 12;46(23):6911-20. Epub 2007 May 16. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17503783 17503783]
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<br />
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Created with the participation of [[User:Osnat Herzberg|Osnat Herzberg]], [[User:Eran Hodis|Eran Hodis]], [[User:Joel L. Sussman|Joel L. Sussman]], [[User:Jaime Prilusky|Jaime Prilusky]].
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</StructureSection>
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[[Category:Topic Page]]

Revision as of 13:25, 10 June 2012

Hyaluronidase complex with hyaluronic acid disaccharide and dimethylarsinate, 1c82

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Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

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