4eaz
From Proteopedia
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{{STRUCTURE_4eaz| PDB=4eaz | SCENE= }} | {{STRUCTURE_4eaz| PDB=4eaz | SCENE= }} | ||
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===Vgll1-TEAD4 structure=== | ===Vgll1-TEAD4 structure=== | ||
| + | {{ABSTRACT_PUBMED_22632831}} | ||
| + | ==Function== | ||
| + | [[http://www.uniprot.org/uniprot/VGLL1_MOUSE VGLL1_MOUSE]] May act as a specific coactivator for the mammalian TEFs (By similarity). [[http://www.uniprot.org/uniprot/TEAD4_MOUSE TEAD4_MOUSE]] Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds specifically and non-cooperatively to the Sph and GT-IIC 'enhansons' (5'-GTGGAATGT-3') and activates transcription. Binds to the M-CAT motif (By similarity). Might play a role in the embryonic development of skeletal muscle. | ||
==About this Structure== | ==About this Structure== | ||
[[4eaz]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EAZ OCA]. | [[4eaz]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EAZ OCA]. | ||
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| + | ==Reference== | ||
| + | <ref group="xtra">PMID:022632831</ref><references group="xtra"/><references/> | ||
[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
[[Category: Pobbati, A V.]] | [[Category: Pobbati, A V.]] | ||
Revision as of 12:40, 3 July 2013
Contents |
Vgll1-TEAD4 structure
Template:ABSTRACT PUBMED 22632831
Function
[VGLL1_MOUSE] May act as a specific coactivator for the mammalian TEFs (By similarity). [TEAD4_MOUSE] Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds specifically and non-cooperatively to the Sph and GT-IIC 'enhansons' (5'-GTGGAATGT-3') and activates transcription. Binds to the M-CAT motif (By similarity). Might play a role in the embryonic development of skeletal muscle.
About this Structure
4eaz is a 4 chain structure with sequence from Mus musculus. Full crystallographic information is available from OCA.
Reference
- Pobbati AV, Chan SW, Lee I, Song H, Hong W. Structural and functional similarity between the Vgll1-TEAD and the YAP-TEAD complexes. Structure. 2012 Jul 3;20(7):1135-40. Epub 2012 May 24. PMID:22632831 doi:10.1016/j.str.2012.04.004
