4fc2
From Proteopedia
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{{STRUCTURE_4fc2| PDB=4fc2 | SCENE= }} | {{STRUCTURE_4fc2| PDB=4fc2 | SCENE= }} | ||
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===Crystal structure of mouse poly(ADP-ribose) glycohydrolase (PARG) catalytic domain=== | ===Crystal structure of mouse poly(ADP-ribose) glycohydrolase (PARG) catalytic domain=== | ||
| + | ==Function== | ||
| + | [[http://www.uniprot.org/uniprot/PARG_MOUSE PARG_MOUSE]] Poly(ADP-ribose) synthesized after DNA damage is only present transiently and is rapidly degraded by poly(ADP-ribose) glycohydrolase. PARG acts both as an endo- and exoglycosidase, releasing PAR of different length as well as ADP-ribose monomers. Required for retinoid acid-dependent gene transactivation, probably by dePARsylating histone demethylase KDM4D, allowing chromatin derepression at RAR-dependent gene promoters (By similarity). | ||
==About this Structure== | ==About this Structure== | ||
| - | [[4fc2]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/ | + | [[4fc2]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FC2 OCA]. |
| - | [[Category: | + | [[Category: Lk3 transgenic mice]] |
[[Category: Cheng, Z.]] | [[Category: Cheng, Z.]] | ||
[[Category: Wang, Z.]] | [[Category: Wang, Z.]] | ||
Revision as of 06:12, 29 January 2014
Crystal structure of mouse poly(ADP-ribose) glycohydrolase (PARG) catalytic domain
Function
[PARG_MOUSE] Poly(ADP-ribose) synthesized after DNA damage is only present transiently and is rapidly degraded by poly(ADP-ribose) glycohydrolase. PARG acts both as an endo- and exoglycosidase, releasing PAR of different length as well as ADP-ribose monomers. Required for retinoid acid-dependent gene transactivation, probably by dePARsylating histone demethylase KDM4D, allowing chromatin derepression at RAR-dependent gene promoters (By similarity).
About this Structure
4fc2 is a 4 chain structure with sequence from Lk3 transgenic mice. Full crystallographic information is available from OCA.
Categories: Lk3 transgenic mice | Cheng, Z. | Wang, Z. | Xu, W. | Hydrolase | Mouse | Parg
