2rci
From Proteopedia
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[[Image:2rci.png|left|200px]] | [[Image:2rci.png|left|200px]] | ||
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{{STRUCTURE_2rci| PDB=2rci | SCENE= }} | {{STRUCTURE_2rci| PDB=2rci | SCENE= }} | ||
===High-resolution crystal structure of activated Cyt2Ba monomer from Bacillus thuringiensis subsp. israelensis=== | ===High-resolution crystal structure of activated Cyt2Ba monomer from Bacillus thuringiensis subsp. israelensis=== | ||
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==See Also== | ==See Also== | ||
*[[Delta-endotoxin|Delta-endotoxin]] | *[[Delta-endotoxin|Delta-endotoxin]] | ||
| - | *[[Insecticidal delta-endotoxin Cyt2Ba from Bacillus thuringiensis|Insecticidal delta-endotoxin Cyt2Ba from Bacillus thuringiensis]] | ||
==Reference== | ==Reference== | ||
Revision as of 06:51, 27 July 2012
Contents |
High-resolution crystal structure of activated Cyt2Ba monomer from Bacillus thuringiensis subsp. israelensis
The Cyt family of proteins consists of delta-endotoxins expressed during sporulation of several subspecies of Bacillus thuringiensis. Its members possess insecticidal, hemolytic, and cytolytic activities through pore formation and attract attention due to their potential use as vehicles for targeted membrane destruction. The delta-endotoxins of subsp. israelensis include three Cyt species: a major Cyt1Aa and two minor proteins, Cyt2Ba and Cyt1Ca. A cleaved Cyt protein that lacks the N- and C-terminal segments forms a toxic monomer. Here, we describe the crystal structure of Cyt2Ba, cleaved at its amino and carboxy termini by bacterial endogenous protease(s). Overall, its fold resembles that of the previously described volvatoxin A2 and the nontoxic form of Cyt2Aa. The structural similarity between these three proteins may provide information regarding the mechanism(s) of membrane-perforating toxins.
High-resolution crystal structure of activated Cyt2Ba monomer from Bacillus thuringiensis subsp. israelensis., Cohen S, Dym O, Albeck S, Ben-Dov E, Cahan R, Firer M, Zaritsky A, J Mol Biol. 2008 Jul 25;380(5):820-7. Epub 2008 May 11. PMID:18571667
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
About this Structure
2rci is a 1 chain structure of Delta-endotoxin with sequence from Bacillus thuringiensis serovar israelensis. Full crystallographic information is available from OCA.
See Also
Reference
- Cohen S, Dym O, Albeck S, Ben-Dov E, Cahan R, Firer M, Zaritsky A. High-resolution crystal structure of activated Cyt2Ba monomer from Bacillus thuringiensis subsp. israelensis. J Mol Biol. 2008 Jul 25;380(5):820-7. Epub 2008 May 11. PMID:18571667 doi:10.1016/j.jmb.2008.05.010
