4dcl

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[[Image:4dcl.png|left|200px]]
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==Computationally Designed Self-assembling tetrahedron protein, T308, Crystallized in space group F23==
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<StructureSection load='4dcl' size='340' side='right' caption='[[4dcl]], [[Resolution|resolution]] 3.35&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4dcl]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus_subsp._aureus Staphylococcus aureus subsp. aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DCL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4DCL FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3v4e|3v4e]]</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">SACOL2570 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=46170 Staphylococcus aureus subsp. aureus])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4dcl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4dcl OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4dcl RCSB], [http://www.ebi.ac.uk/pdbsum/4dcl PDBsum]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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We describe a general computational method for designing proteins that self-assemble to a desired symmetric architecture. Protein building blocks are docked together symmetrically to identify complementary packing arrangements, and low-energy protein-protein interfaces are then designed between the building blocks in order to drive self-assembly. We used trimeric protein building blocks to design a 24-subunit, 13-nm diameter complex with octahedral symmetry and a 12-subunit, 11-nm diameter complex with tetrahedral symmetry. The designed proteins assembled to the desired oligomeric states in solution, and the crystal structures of the complexes revealed that the resulting materials closely match the design models. The method can be used to design a wide variety of self-assembling protein nanomaterials.
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Computational design of self-assembling protein nanomaterials with atomic level accuracy.,King NP, Sheffler W, Sawaya MR, Vollmar BS, Sumida JP, Andre I, Gonen T, Yeates TO, Baker D Science. 2012 Jun 1;336(6085):1171-4. PMID:22654060<ref>PMID:22654060</ref>
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The line below this paragraph, containing "STRUCTURE_4dcl", creates the "Structure Box" on the page.
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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or leave the SCENE parameter empty for the default display.
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{{STRUCTURE_4dcl| PDB=4dcl | SCENE= }}
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===Computationally Designed Self-assembling tetrahedron protein, T308, Crystallized in space group F23===
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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== References ==
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<references/>
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The line below this paragraph, {{ABSTRACT_PUBMED_22654060}}, adds the Publication Abstract to the page
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 22654060 is the PubMed ID number.
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</StructureSection>
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{{ABSTRACT_PUBMED_22654060}}
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==About this Structure==
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[[4dcl]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus_subsp._aureus Staphylococcus aureus subsp. aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DCL OCA].
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==Reference==
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<ref group="xtra">PMID:022654060</ref><references group="xtra"/>
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[[Category: Staphylococcus aureus subsp. aureus]]
[[Category: Staphylococcus aureus subsp. aureus]]
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[[Category: Baker, D.]]
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[[Category: Baker, D]]
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[[Category: King, N P.]]
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[[Category: King, N P]]
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[[Category: Sawaya, M R.]]
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[[Category: Sawaya, M R]]
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[[Category: Sheffler, W.]]
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[[Category: Sheffler, W]]
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[[Category: Yeates, T O.]]
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[[Category: Yeates, T O]]
[[Category: Self assembling tetrahedron design]]
[[Category: Self assembling tetrahedron design]]
[[Category: Transferase]]
[[Category: Transferase]]

Revision as of 14:25, 4 January 2015

Computationally Designed Self-assembling tetrahedron protein, T308, Crystallized in space group F23

4dcl, resolution 3.35Å

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