1gjy

From Proteopedia

Revision as of 13:09, 30 October 2007

THE X-RAY STRUCTURE OF THE SORCIN CALCIUM BINDING DOMAIN (SCBD) PROVIDES INSIGHT INTO THE PHOSPHORYLATION AND CALCIUM DEPENDENT PROCESSESS

Overview

Sorcin is a 21.6 kDa calcium binding protein, expressed in a number of, mammalian tissues that belongs to the small, recently identified, penta-EF-hand (PEF) family. Like all members of this family, sorcin, undergoes a Ca2+-dependent translocation from cytosol to membranes where, it binds to target proteins. For sorcin, the targets differ in different, tissues, indicating that it takes part in a number of Ca2+-regulated, processes. The sorcin monomer is organized in two domains like in all PEF, proteins: a flexible, hydrophobic, glycine-rich N-terminal region and a, calcium binding C-terminal domain. In vitro, the PEF proteins are dimeric, in their Ca2+-free form, but have a marked tendency to precipitate when, bound to calcium. Stabilization of the dimeric structure is achieved by, ... [(full description)]

About this Structure

1GJY is a [Single protein] structure of sequence from [Cricetulus longicaudatus] with SO4 as [ligand]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].

Reference

The crystal structure of the sorcin calcium binding domain provides a model of Ca2+-dependent processes in the full-length protein., Ilari A, Johnson KA, Nastopoulos V, Verzili D, Zamparelli C, Colotti G, Tsernoglou D, Chiancone E, J Mol Biol. 2002 Mar 29;317(3):447-58. PMID:11922676

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