Hirudin
From Proteopedia
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[[Image:1hic.png|left|200px|thumb|NMR Structure of Hirudin, [[1hic]]]] | [[Image:1hic.png|left|200px|thumb|NMR Structure of Hirudin, [[1hic]]]] | ||
{{STRUCTURE_1hic| PDB=1hic | SIZE=400| SCENE=Hirudin/Cv/1 |right|CAPTION=Hirudin, [[1hic]] }} | {{STRUCTURE_1hic| PDB=1hic | SIZE=400| SCENE=Hirudin/Cv/1 |right|CAPTION=Hirudin, [[1hic]] }} | ||
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[[Hirudin]] (Hir) is a powerful anticoagulant which is found in the leech salivary glands. It is an inhibitor of thrombin (Thr) which converts [[Fibrinogen|fibrinogen]] to [[Fibrin|fibrin]] upon blood clotting. Thrombin is produced upon enzymatic cleavage of prothrombin (ProThr). Hirugen (Hirg) is a dodecapeptide of the C-terminal of Hir (sequence NDGDFEEIPEEYL). The images at the left and at the right correspond to one representative Hirudin, ''i.e.'' the NMR Structure of Hirudin ([[1hic]]). | [[Hirudin]] (Hir) is a powerful anticoagulant which is found in the leech salivary glands. It is an inhibitor of thrombin (Thr) which converts [[Fibrinogen|fibrinogen]] to [[Fibrin|fibrin]] upon blood clotting. Thrombin is produced upon enzymatic cleavage of prothrombin (ProThr). Hirugen (Hirg) is a dodecapeptide of the C-terminal of Hir (sequence NDGDFEEIPEEYL). The images at the left and at the right correspond to one representative Hirudin, ''i.e.'' the NMR Structure of Hirudin ([[1hic]]). | ||
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== 3D Structures of Hirudin == | == 3D Structures of Hirudin == | ||
| - | + | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | |
=== Hirudin === | === Hirudin === | ||
Revision as of 09:04, 10 March 2013
Hirudin (Hir) is a powerful anticoagulant which is found in the leech salivary glands. It is an inhibitor of thrombin (Thr) which converts fibrinogen to fibrin upon blood clotting. Thrombin is produced upon enzymatic cleavage of prothrombin (ProThr). Hirugen (Hirg) is a dodecapeptide of the C-terminal of Hir (sequence NDGDFEEIPEEYL). The images at the left and at the right correspond to one representative Hirudin, i.e. the NMR Structure of Hirudin (1hic).
3D Structures of Hirudin
Updated on 10-March-2013
Hirudin
1hic, 2hir, 4hir, 5hir, 6hir – Hir – NMR
2joo - Hir – NMR
Hirudin + Thrombin light and heavy chains
1hrt, 3htc, 4htc - Hir +hThr L&H chains
3da9 - Hir peptide+hThr L&H chains
3qtv, 3qwc, 3qx5 - Hir peptide + hThr L&H chains + pyridine derivative
3rlw, 3rly, 3rm0, 3rm2, 3rml, 3rmm, 3rmn, 3rmo - Hir peptide + hThr L&H chains + inhibitor
3qto - Hir +hThr L&H chains + pyridine derivative
Hirugen + Thrombin light and heavy chains
2zhe, 2zhf, 2zhw, 2zg0, 2zfq, 2zfr, 1c5l, 1hxf, 1hah, 1hai, 1abi, 1abj, 1hgt, 2uuf - Hirg+ hThr L&H chains
Hirugen + Prothrombin
2cn0, 3c1k – Hirg+ hProThr
1t4u, 1t4v, 1o5g, 1g30, 1g32, 1twx, 3tu7 - Hirg+hProThr+inhibitor
Hirugen + Prethrombin
1hag – Hirg+hPreThr
Hirugen + Thrombin heavy chain
1nm6 – Hirg+ hThr H chain
1nt1 - Hirg+ hThr H chain+inhibitor
Hirugen + Thrombin light and heavy chains+inhibitor
1fph, 7kme - Hirg +hThr L&H chains+polypeptide
1hxe - Hirg +hThr L&H chains+Rb
1ypk, 1riw, 1mu6, 1mu8, 1mue, 1no9, 1oyt, 1o2g, 1ny2, 1gj4, 1gj5, 1kts, 1ktt, 1ghv, 1ghw, 1ghx, 1ghy, 1h8i, 1h8d, 1c5n, 1c5o, 1c1u, 1c1v, 1c1w, 1qj1, 1qj6, 1qj7, 1qbv, 1bcu, 1a2c, 1a61, 1a46, 1a5g, 1b5g, 1ad8, 1ai8, 1tom, 1bmm, 1bmn, 1lhc, 1lhd, 1lhe, 1lhf, 1lhg, 1uma, 1aht, 1fpc, 3hat, 1tmu, 1dwb, 1dwc, 1dwd, 1dwe, 1tmb, 3f68, 3eq0, 3dt0, 3dux, 3dhk, 2znk, 2zo3, 3d49, 2zhq, 2zi2, 2ziq, 2zff, 2zfp, 2zgb, 2zgx, 2zf0, 2zc9, 2zda, 2zdv, 3egk, 2pw8, 3c27, 2r2m, 2cf8, 2cf9, 2bdy, 2v3h, 2v3o, 1w7g, 1ype, 1ypg, 1ypj, 3biu, 3biv, 1doj, 1ypl, 1ypm, 1vzq, 1way, 1wbg, 1k21, 1k22, 1afe, 1ae8 ,1a3b, 1a3e, 1vr1, 2bvr, 2bvs, 2bvx, 2bxt, 2bxu, 2gde, 2pks, 3ldx, 3p17 – Hirg+ hThr L&H chains+inhibitor
Hirugen+Thrombin light and heavy chains+ε-thrombin
1vit - Hirg+hThr L&H chains+epsilon-hThr
Hirugen+ α-Thrombin +inhibitor
1zrb, 1z71, 1sl3, 1ta2, 1ta6, 1zgi, 1zgv, 2uuk, 2uuj, 2jh0, 2jh5, 2jh6, 2c8w, 2c8x, 2c8y, 2c8z, 2c90, 2c93, 8kme – Hirg+α-hThr+inhibitor
