2hth
From Proteopedia
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==Overview== | ==Overview== | ||
| - | The ESCRT-I and ESCRT-II complexes help sort ubiquitinated proteins into | + | The ESCRT-I and ESCRT-II complexes help sort ubiquitinated proteins into vesicles that accumulate within multivesicular bodies (MVBs). Crystallographic and biochemical analyses reveal that the GLUE domain of the human ESCRT-II EAP45 (also called VPS36) subunit is a split pleckstrin-homology domain that binds ubiquitin along one edge of the beta-sandwich. The structure suggests how human ESCRT-II can couple recognition of ubiquitinated cargoes and endosomal phospholipids during MVB protein sorting. |
==Disease== | ==Disease== | ||
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[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
| - | [[Category: Alam, S | + | [[Category: Alam, S L.]] |
| - | [[Category: Hill, C | + | [[Category: Hill, C P.]] |
| - | [[Category: Sundquist, W | + | [[Category: Sundquist, W I.]] |
| - | [[Category: Whitby, F | + | [[Category: Whitby, F G.]] |
[[Category: glue domain]] | [[Category: glue domain]] | ||
[[Category: ph domain]] | [[Category: ph domain]] | ||
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[[Category: viral budding]] | [[Category: viral budding]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 17:45:35 2008'' |
Revision as of 15:45, 21 February 2008
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Structural basis for ubiquitin recognition by the human EAP45/ESCRT-II GLUE domain
Contents |
Overview
The ESCRT-I and ESCRT-II complexes help sort ubiquitinated proteins into vesicles that accumulate within multivesicular bodies (MVBs). Crystallographic and biochemical analyses reveal that the GLUE domain of the human ESCRT-II EAP45 (also called VPS36) subunit is a split pleckstrin-homology domain that binds ubiquitin along one edge of the beta-sandwich. The structure suggests how human ESCRT-II can couple recognition of ubiquitinated cargoes and endosomal phospholipids during MVB protein sorting.
Disease
Known disease associated with this structure: Cleft palate, isolated OMIM:[191339]
About this Structure
2HTH is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Structural basis for ubiquitin recognition by the human ESCRT-II EAP45 GLUE domain., Alam SL, Langelier C, Whitby FG, Koirala S, Robinson H, Hill CP, Sundquist WI, Nat Struct Mol Biol. 2006 Nov;13(11):1029-30. Epub 2006 Oct 22. PMID:17057716
Page seeded by OCA on Thu Feb 21 17:45:35 2008
