Journal:FLS:1
From Proteopedia
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<Structure load='3HSWa.pdb' size='500' frame='true' align='right' caption='' scene='Journal:FLS:1/Cv/1' /> | <Structure load='3HSWa.pdb' size='500' frame='true' align='right' caption='' scene='Journal:FLS:1/Cv/1' /> | ||
=== Crystal structure of porcine pancreatic phospholipase A<sub>2</sub> in complex with 2-methoxycyclohexa-2-5-diene-1,4-dione === | === Crystal structure of porcine pancreatic phospholipase A<sub>2</sub> in complex with 2-methoxycyclohexa-2-5-diene-1,4-dione === | ||
| - | <big>K V Dileep, I Tintu, P K Mandal, P Karthe, M Haridas and C Sadasivan</big><ref >none yet</ref> | + | <big>K. V. Dileep, I. Tintu, P. K. Mandal, P. Karthe, M. Haridas and C. Sadasivan</big><ref >none yet</ref> |
<hr/> | <hr/> | ||
<b>Molecular Tour</b><br> | <b>Molecular Tour</b><br> | ||
Revision as of 12:50, 24 June 2012
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Crystal structure of porcine pancreatic phospholipase A2 in complex with 2-methoxycyclohexa-2-5-diene-1,4-dione
K. V. Dileep, I. Tintu, P. K. Mandal, P. Karthe, M. Haridas and C. Sadasivan[1]
Molecular Tour
possesses anti-inflammatory activity. The binding of curcumin with PLA2 was studied using X-ray crystallography. Since the electron density found in the active site did not match with curcumin, (the photo-degraded product of curcumin) in the unexplained electron density. To understand the , molecular docking studies was carried out. with respect to the ligand position and identified that of PLA2 with a binding energy -16.81 Kcal/mol. The binding mode is in such a manner that it can prevent the entry of substrate to the hydrophobic active site. These studies indicate that curcumin can be act as an inhibitor to PLA2.
- ↑ none yet
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