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1w3m

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[[Image:1w3m.png|left|200px]]
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==Crystal structure of tsushimycin==
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<StructureSection load='1w3m' size='340' side='right' caption='[[1w3m]], [[Resolution|resolution]] 1.00&Aring;' scene=''>
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== Structural highlights ==
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[[1w3m]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Actinoplanes_friuliensis Actinoplanes friuliensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W3M OCA]. <br>
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<b>Activity:</b> <span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span><br>
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== Publication Abstract from PubMed ==
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The amphomycin derivative tsushimycin has been crystallized and its structure determined at 1.0 A resolution. The asymmetric unit contains 12 molecules and with 1300 independent atoms this structure is one of the largest solved using ab initio direct methods. The antibiotic is comprised of a cyclodecapeptide core, an exocyclic amino acid and a fatty-acid residue. Its backbone adopts a saddle-like conformation that is stabilized by a Ca2+ ion bound within the peptide ring and accounts for the Ca2+-dependence of this antibiotic class. Additional Ca2+ ions link the antibiotic molecules to dimers that enclose an empty space resembling a binding cleft. The dimers possess a large hydrophobic surface capable of interacting with the bacterial cell membrane. The antibiotic daptomycin may exhibit a similar conformation, as the amino-acid sequence is conserved at positions involved in Ca2+ binding.
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{{STRUCTURE_1w3m| PDB=1w3m | SCENE= }}
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Structure of the lipopeptide antibiotic tsushimycin.,Bunkoczi G, Vertesy L, Sheldrick GM Acta Crystallogr D Biol Crystallogr. 2005 Aug;61(Pt 8):1160-4. Epub 2005, Jul 20. PMID:16041082<ref>PMID:16041082</ref>
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===Crystal structure of tsushimycin===
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
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== References ==
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{{ABSTRACT_PUBMED_16041082}}
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<references/>
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__TOC__
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==About this Structure==
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</StructureSection>
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[[1w3m]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Actinoplanes_friuliensis Actinoplanes friuliensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W3M OCA].
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==Reference==
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<ref group="xtra">PMID:016041082</ref><references group="xtra"/>
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[[Category: Actinoplanes friuliensis]]
[[Category: Actinoplanes friuliensis]]
[[Category: Bunkoczi, G.]]
[[Category: Bunkoczi, G.]]

Revision as of 08:41, 30 April 2014

Crystal structure of tsushimycin

1w3m, resolution 1.00Å

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