2ykh

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[[Image:2ykh.png|left|200px]]
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==Sensor region of a sensor histidine kinase==
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<StructureSection load='2ykh' size='340' side='right' caption='[[2ykh]], [[Resolution|resolution]] 2.78&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2ykh]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YKH OCA]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2ykf|2ykf]]</td></tr>
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<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span></td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ykh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ykh OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ykh RCSB], [http://www.ebi.ac.uk/pdbsum/2ykh PDBsum]</span></td></tr>
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<table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Two-component systems, a sensor histidine kinase (HK) and a response regulator (RR), are ubiquitous signaling systems that allow prokaryotes to respond to external challenges. HKs normally have sensing modules and highly conserved cytosolic histidine kinase and ATPase domains. The interaction between the activated phosphohistidine and the cognate RR allows an external signal to be passed from the exterior of gram-positive bacteria (GPB) to the cytoplasm. Orthologs of the PdtaS/PdtaR regulatory system, found in most GPB phyla, are unusual in two respects. The HK is not membrane anchored, and the RR acts at the level of transcriptional antitermination. The structure of the complete sensor region of the cytosolic HK, PdtaS, from Mycobacterium tuberculosis consists of closely linked GAF and PAS domains. The structure and sequence analysis suggest that the PdtaS/PdtaR regulatory system is structurally equivalent to the EutW/EutV system regulating ethanolamine catabolism in some phyla but that the effector for the PAS domain is not ethanolamine in the Actinobacteria.
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{{STRUCTURE_2ykh| PDB=2ykh | SCENE= }}
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The sensor region of the ubiquitous cytosolic sensor kinase, PdtaS, contains PAS and GAF domain sensing modules.,Preu J, Panjikar S, Morth P, Jaiswal R, Karunakar P, Tucker PA J Struct Biol. 2012 Feb;177(2):498-505. Epub 2011 Nov 17. PMID:22115998<ref>PMID:22115998</ref>
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===Sensor region of a sensor histidine kinase===
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
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</div>
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{{ABSTRACT_PUBMED_22115998}}
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== References ==
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<references/>
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==About this Structure==
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__TOC__
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[[2ykh]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YKH OCA].
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</StructureSection>
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==Reference==
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<ref group="xtra">PMID:022115998</ref><references group="xtra"/>
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[[Category: Histidine kinase]]
[[Category: Histidine kinase]]
[[Category: Mycobacterium tuberculosis]]
[[Category: Mycobacterium tuberculosis]]

Revision as of 07:52, 14 May 2014

Sensor region of a sensor histidine kinase

2ykh, resolution 2.78Å

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