3vtm

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'''Unreleased structure'''
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{{STRUCTURE_3vtm| PDB=3vtm | SCENE= }}
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===Structure of heme transport protein IsdH-NEAT3 from S. aureus in complex with Indium-porphyrin===
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{{ABSTRACT_PUBMED_21797259}}
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The entry 3vtm is ON HOLD until Paper Publication
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==Function==
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[[http://www.uniprot.org/uniprot/ISDH_STAAM ISDH_STAAM]] Binds human plasma haptoglobin-hemoglobin complexes, haptoglobin and hemoglobin. Binds haptoglobin-hemoglobin complexes with significantly higher affinity than haptoglobin alone (By similarity).
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Authors: Vu, N.T., Caaveiro, J.M.M., Moriwaki, Y., Tsumoto, K.
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==About this Structure==
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[[3vtm]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus_subsp._aureus_mu50 Staphylococcus aureus subsp. aureus mu50]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VTM OCA].
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Description: Structure of heme transport protein IsdH-NEAT3 from S. aureus in complex with Indium-porphyrin
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==Reference==
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<ref group="xtra">PMID:021797259</ref><ref group="xtra">PMID:018667422</ref><references group="xtra"/><references/>
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[[Category: Staphylococcus aureus subsp. aureus mu50]]
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[[Category: Caaveiro, J M.M.]]
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[[Category: Moriwaki, Y.]]
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[[Category: Tsumoto, K.]]
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[[Category: Vu, N T.]]
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[[Category: Cell wall]]
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[[Category: Heme binding]]
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[[Category: Heme transport]]
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[[Category: Heme-binding protein]]
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[[Category: Hemin]]
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[[Category: Indium]]
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[[Category: Metal selectivity]]
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[[Category: Metalloporphyrin]]
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[[Category: Neat domain]]
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[[Category: Ppix]]

Revision as of 07:25, 16 May 2013

Template:STRUCTURE 3vtm

Contents

Structure of heme transport protein IsdH-NEAT3 from S. aureus in complex with Indium-porphyrin

Template:ABSTRACT PUBMED 21797259

Function

[ISDH_STAAM] Binds human plasma haptoglobin-hemoglobin complexes, haptoglobin and hemoglobin. Binds haptoglobin-hemoglobin complexes with significantly higher affinity than haptoglobin alone (By similarity).

About this Structure

3vtm is a 2 chain structure with sequence from Staphylococcus aureus subsp. aureus mu50. Full crystallographic information is available from OCA.

Reference

  • Moriwaki Y, Caaveiro JM, Tanaka Y, Tsutsumi H, Hamachi I, Tsumoto K. Molecular basis of recognition of antibacterial porphyrins by heme-transporter IsdH-NEAT3 of Staphylococcus aureus. Biochemistry. 2011 Aug 30;50(34):7311-20. Epub 2011 Aug 4. PMID:21797259 doi:10.1021/bi200493h
  • Watanabe M, Tanaka Y, Suenaga A, Kuroda M, Yao M, Watanabe N, Arisaka F, Ohta T, Tanaka I, Tsumoto K. Structural basis for multimeric heme complexation through a specific protein-heme interaction: the case of the third neat domain of IsdH from Staphylococcus aureus. J Biol Chem. 2008 Oct 17;283(42):28649-59. Epub 2008 Jul 30. PMID:18667422 doi:10.1074/jbc.M803383200

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