2rgf
From Proteopedia
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==Overview== | ==Overview== | ||
| - | The solution structure of the Ras-binding domain (RBD) of Ral | + | The solution structure of the Ras-binding domain (RBD) of Ral guanine-nucleotide exchange factor RalGEF was solved by NMR spectroscopy. The overall structure is similar to that of Raf-RBD, another effector of Ras, although the sequence identity is only 13%. 15N chemical shifts changes in the complex of RalGEF-RBD with Ras indicate an interaction similar to the intermolecular beta-sheet observed for the complex between Ras and Raf-RBD. |
==About this Structure== | ==About this Structure== | ||
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[[Category: Geyer, M.]] | [[Category: Geyer, M.]] | ||
[[Category: Herrmann, C.]] | [[Category: Herrmann, C.]] | ||
| - | [[Category: Kalbitzer, H | + | [[Category: Kalbitzer, H R.]] |
[[Category: Wittinghofer, A.]] | [[Category: Wittinghofer, A.]] | ||
[[Category: ralgds]] | [[Category: ralgds]] | ||
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[[Category: rbd]] | [[Category: rbd]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 18:47:06 2008'' |
Revision as of 16:47, 21 February 2008
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RBD OF RAL GUANOSINE-NUCLEOTIDE EXCHANGE FACTOR (PROTEIN), NMR, 10 STRUCTURES
Overview
The solution structure of the Ras-binding domain (RBD) of Ral guanine-nucleotide exchange factor RalGEF was solved by NMR spectroscopy. The overall structure is similar to that of Raf-RBD, another effector of Ras, although the sequence identity is only 13%. 15N chemical shifts changes in the complex of RalGEF-RBD with Ras indicate an interaction similar to the intermolecular beta-sheet observed for the complex between Ras and Raf-RBD.
About this Structure
2RGF is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Structure of the Ras-binding domain of RalGEF and implications for Ras binding and signalling., Geyer M, Herrmann C, Wohlgemuth S, Wittinghofer A, Kalbitzer HR, Nat Struct Biol. 1997 Sep;4(9):694-9. PMID:9302994
Page seeded by OCA on Thu Feb 21 18:47:06 2008
Categories: Homo sapiens | Single protein | Geyer, M. | Herrmann, C. | Kalbitzer, H R. | Wittinghofer, A. | Ralgds | Ralgef | Ras | Ras-binding domain | Rbd
