Hox protein

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<scene name='Sandbox_Reserved_169/Scr_mg/6'>Scr major groove contacts</scene>
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<scene name='Sandbox_Reserved_169/Scr_mg/4'>Scr minor groove contacts</scene>
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<scene name='Sandbox_Reserved_169/Scr_mg/7'>Scr minor groove contacts</scene>
[[Image:Cell2007-Fig4.jpg‎ |thumb|left|300px|Caption <ref name="joshi"/>.]]
[[Image:Cell2007-Fig4.jpg‎ |thumb|left|300px|Caption <ref name="joshi"/>.]]

Revision as of 20:56, 2 July 2012

This Sandbox is Reserved from 22 April 2012, through 31 August 2012 for use in the course "Protein DNA" taught by Remo_Rohs at the La Canada High School, USA. This reservation includes Sandbox Reserved 169 through Sandbox Reserved 170.
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Hox Proteins Specifically Recognize the Sequence-Dependent Shape of the Minor Groove

Biological Role of Hox Proteins

Figure 1: Crystal structure of Exd-Scr-DNA ternary complex; PDB ID# 2R5Z .
Figure 1: Crystal structure of Exd-Scr-DNA ternary complex; PDB ID# 2R5Z [1].
Figure 2: Latent specificity of Hox proteins .
Figure 2: Latent specificity of Hox proteins [2].

Hox proteins are transcription factors that play a key role in the embryonic development across species. In Drosophila eight Hox proteins are responsible for the development of different body segments of the fly, for example its antennae, wings, or legs. Various Hox proteins execute these distinct functions through binding to closely related but different in vivo binding sites. This page discusses the mechanisms through which Hox proteins recognize their DNA binding sites with very high binding specificity.

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Caption .
Caption [1].
Image:Slattery-etal-Figure6.jpg
Caption [2].
Caption .
Caption [1].

References

  1. ↑ 1.0 1.1 1.2 Joshi R, Passner JM, Rohs R, Jain R, Sosinsky A, Crickmore MA, Jacob V, Aggarwal AK, Honig B, Mann RS. Functional specificity of a Hox protein mediated by the recognition of minor groove structure. Cell. 2007;131(3):530-43.
  2. ↑ 2.0 2.1 Slattery M, Riley T, Liu P, Abe N, Gomez-Alcala P, Dror I, Zhou T, Rohs R, Honig B, Bussemaker HJ, Mann RS. Cofactor binding evokes latent differences in DNA binding specificity between Hox proteins. Cell. 2011;147(6):1270-82.
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