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4akn

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[[Image:4akn.jpg|left|200px]]
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[[Image:4akn.png|left|200px]]
{{STRUCTURE_4akn| PDB=4akn | SCENE= }}
{{STRUCTURE_4akn| PDB=4akn | SCENE= }}
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===N-Terminal Bromodomain of Human BRD2 With tbutyl-phenyl-amino- dimethyl-oxazolyl-quinoline-carboxylic acid===
===N-Terminal Bromodomain of Human BRD2 With tbutyl-phenyl-amino- dimethyl-oxazolyl-quinoline-carboxylic acid===
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{{ABSTRACT_PUBMED_22437115}}
 
==About this Structure==
==About this Structure==

Revision as of 07:08, 14 November 2012

Image:4akn.png

Template:STRUCTURE 4akn

N-Terminal Bromodomain of Human BRD2 With tbutyl-phenyl-amino- dimethyl-oxazolyl-quinoline-carboxylic acid

About this Structure

4akn is a 3 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Seal J, Lamotte Y, Donche F, Bouillot A, Mirguet O, Gellibert F, Nicodeme E, Krysa G, Kirilovsky J, Beinke S, McCleary S, Rioja I, Bamborough P, Chung CW, Gordon L, Lewis T, Walker AL, Cutler L, Lugo D, Wilson DM, Witherington J, Lee K, Prinjha RK. Identification of a novel series of BET family bromodomain inhibitors: binding mode and profile of I-BET151 (GSK1210151A). Bioorg Med Chem Lett. 2012 Apr 15;22(8):2968-72. Epub 2012 Feb 24. PMID:22437115 doi:10.1016/j.bmcl.2012.02.041

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OCA

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