4fc7

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[[Image:4fc7.png|left|200px]]
 
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{{STRUCTURE_4fc7| PDB=4fc7 | SCENE= }}
{{STRUCTURE_4fc7| PDB=4fc7 | SCENE= }}
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===Studies on DCR shed new light on peroxisomal beta-oxidation: Crystal structure of the ternary complex of pDCR===
===Studies on DCR shed new light on peroxisomal beta-oxidation: Crystal structure of the ternary complex of pDCR===
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{{ABSTRACT_PUBMED_22745130}}
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{{ABSTRACT_PUBMED_22745130}}
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==Function==
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[[http://www.uniprot.org/uniprot/DECR2_HUMAN DECR2_HUMAN]] Auxiliary enzyme of beta-oxidation. Participates in the degradation of unsaturated fatty enoyl-CoA esters having double bonds in both even- and odd-numbered positions in peroxisome. Catalyzes the NADP-dependent reduction of 2,4-dienoyl-CoA to yield trans-3-enoyl-CoA. Has activity towards short and medium chain 2,4-dienoyl-CoAs, but also towards 2,4,7,10,13,16,19-docosaheptaenoyl-CoA, suggesting that it does not constitute a rate limiting step in the peroxisomal degradation of docosahexaenoic acid.
==About this Structure==
==About this Structure==
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==Reference==
==Reference==
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<ref group="xtra">PMID:022745130</ref><references group="xtra"/>
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<ref group="xtra">PMID:022745130</ref><references group="xtra"/><references/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Hua, T.]]
[[Category: Hua, T.]]

Revision as of 11:01, 24 July 2013

Template:STRUCTURE 4fc7

Contents

Studies on DCR shed new light on peroxisomal beta-oxidation: Crystal structure of the ternary complex of pDCR

Template:ABSTRACT PUBMED 22745130

Function

[DECR2_HUMAN] Auxiliary enzyme of beta-oxidation. Participates in the degradation of unsaturated fatty enoyl-CoA esters having double bonds in both even- and odd-numbered positions in peroxisome. Catalyzes the NADP-dependent reduction of 2,4-dienoyl-CoA to yield trans-3-enoyl-CoA. Has activity towards short and medium chain 2,4-dienoyl-CoAs, but also towards 2,4,7,10,13,16,19-docosaheptaenoyl-CoA, suggesting that it does not constitute a rate limiting step in the peroxisomal degradation of docosahexaenoic acid.

About this Structure

4fc7 is a 4 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Hua T, Wu D, Ding W, Wang J, Shaw N, Liu ZJ. Studies on human 2, 4 dienoyl CoA reductase (DCR) sheds new light on peroxisomal beta-oxidation of unsaturated fatty acids. J Biol Chem. 2012 Jun 28. PMID:22745130 doi:10.1074/jbc.M112.385351

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OCA

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