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111d

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[[Image:111d.jpg|left|200px]]<br /><applet load="111d" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:111d.jpg|left|200px]]
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caption="111d, resolution 2.250&Aring;" />
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'''CRYSTAL STRUCTURE AND STABILITY OF A DNA DUPLEX CONTAINING A(ANTI).G(SYN) BASE-PAIRS'''<br />
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{{Structure
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|PDB= 111d |SIZE=350|CAPTION= <scene name='initialview01'>111d</scene>, resolution 2.250&Aring;
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|SITE=
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|LIGAND=
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|ACTIVITY=
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|GENE=
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}}
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'''CRYSTAL STRUCTURE AND STABILITY OF A DNA DUPLEX CONTAINING A(ANTI).G(SYN) BASE-PAIRS'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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111D is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=111D OCA].
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111D is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=111D OCA].
==Reference==
==Reference==
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Crystal structure and stability of a DNA duplex containing A(anti).G(syn) base-pairs., Brown T, Leonard GA, Booth ED, Chambers J, J Mol Biol. 1989 May 20;207(2):455-7. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=2754734 2754734]
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Crystal structure and stability of a DNA duplex containing A(anti).G(syn) base-pairs., Brown T, Leonard GA, Booth ED, Chambers J, J Mol Biol. 1989 May 20;207(2):455-7. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/2754734 2754734]
[[Category: Protein complex]]
[[Category: Protein complex]]
[[Category: Booth, E D.]]
[[Category: Booth, E D.]]
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[[Category: mismatched]]
[[Category: mismatched]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 11:37:34 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 09:48:34 2008''

Revision as of 07:48, 20 March 2008

Image:111d.jpg


PDB ID 111d

Drag the structure with the mouse to rotate
, resolution 2.250Å
Coordinates: save as pdb, mmCIF, xml



CRYSTAL STRUCTURE AND STABILITY OF A DNA DUPLEX CONTAINING A(ANTI).G(SYN) BASE-PAIRS


Overview

The synthetic dodecanucleotide d(CGCAAATTGGCG) has been analysed by single-crystal X-ray diffraction techniques and the structure refined to R = 0.16 and 2.25 A resolution, with the location of 94 solvent molecules. The sequence crystallizes as a full turn of a B-DNA helix with ten Watson-Crick base-pairs and two adenine-guanine mispairs. The analysis clearly shows that the mismatches are of the form A(anti).G(syn). Thermal denaturation studies indicate that the stability of the duplex is strongly pH dependent, with a maximum at pH 5.0, suggesting that the base-pair is stabilized by protonation. Three different arrangements have been observed for base-pairs between guanine and adenine and it is likely that A.G mismatch conformation is strongly influenced by dipole-dipole interactions with adjacent base-pairs.

About this Structure

111D is a Protein complex structure of sequences from [1]. Full crystallographic information is available from OCA.

Reference

Crystal structure and stability of a DNA duplex containing A(anti).G(syn) base-pairs., Brown T, Leonard GA, Booth ED, Chambers J, J Mol Biol. 1989 May 20;207(2):455-7. PMID:2754734

Page seeded by OCA on Thu Mar 20 09:48:34 2008

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