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4f7v

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{{STRUCTURE_4f7v| PDB=4f7v | SCENE= }}
{{STRUCTURE_4f7v| PDB=4f7v | SCENE= }}

Revision as of 06:20, 25 July 2012

Image:4f7v.png

Template:STRUCTURE 4f7v

Crystal structure of E. coli HPPK in complex with bisubstrate analogue inhibitor J1D (HP26)

Template:ABSTRACT PUBMED 22727779

About this Structure

4f7v is a 1 chain structure with sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

  • Shi G, Shaw G, Li Y, Wu Y, Yan H, Ji X. Bisubstrate analog inhibitors of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase: New lead exhibits a distinct binding mode. Bioorg Med Chem. 2012 Jul 15;20(14):4303-9. Epub 2012 Jun 6. PMID:22727779 doi:10.1016/j.bmc.2012.05.060
  • Shi G, Blaszczyk J, Ji X, Yan H. Bisubstrate analogue inhibitors of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase: synthesis and biochemical and crystallographic studies. J Med Chem. 2001 Apr 26;44(9):1364-71. PMID:11311059
  • Shi G, Shaw G, Liang YH, Subburaman P, Li Y, Wu Y, Yan H, Ji X. Bisubstrate analogue inhibitors of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase: New design with improved properties. Bioorg Med Chem. 2012 Jan 1;20(1):47-57. Epub 2011 Nov 23. PMID:22169600 doi:10.1016/j.bmc.2011.11.032

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OCA

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