3tik
From Proteopedia
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{{STRUCTURE_3tik| PDB=3tik | SCENE= }} | {{STRUCTURE_3tik| PDB=3tik | SCENE= }} | ||
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===Sterol 14-alpha demethylase (CYP51) from Trypanosoma brucei in complex with the tipifarnib derivative 6-((4-chlorophenyl)(methoxy)(1-methyl-1H-imidazol-5-yl)methyl)-4-(2,6-difluorophenyl)-1-methylquinolin-2(1H)-one=== | ===Sterol 14-alpha demethylase (CYP51) from Trypanosoma brucei in complex with the tipifarnib derivative 6-((4-chlorophenyl)(methoxy)(1-methyl-1H-imidazol-5-yl)methyl)-4-(2,6-difluorophenyl)-1-methylquinolin-2(1H)-one=== | ||
| + | {{ABSTRACT_PUBMED_22777048}} | ||
==About this Structure== | ==About this Structure== | ||
[[3tik]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Trypanosoma_brucei Trypanosoma brucei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TIK OCA]. | [[3tik]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Trypanosoma_brucei Trypanosoma brucei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TIK OCA]. | ||
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| + | ==Reference== | ||
| + | <ref group="xtra">PMID:022777048</ref><references group="xtra"/> | ||
[[Category: Sterol 14-demethylase]] | [[Category: Sterol 14-demethylase]] | ||
[[Category: Trypanosoma brucei]] | [[Category: Trypanosoma brucei]] | ||
Revision as of 06:27, 25 July 2012
Sterol 14-alpha demethylase (CYP51) from Trypanosoma brucei in complex with the tipifarnib derivative 6-((4-chlorophenyl)(methoxy)(1-methyl-1H-imidazol-5-yl)methyl)-4-(2,6-difluorophenyl)-1-methylquinolin-2(1H)-one
Template:ABSTRACT PUBMED 22777048
About this Structure
3tik is a 4 chain structure with sequence from Trypanosoma brucei. Full crystallographic information is available from OCA.
Reference
- Buckner FS, Bahia MT, Suryadevara PK, White KL, Shackleford DM, Chennamaneni NK, Hulverson MA, Laydbak JU, Chatelain E, Scandale I, Verlinde CL, Charman SA, Lepesheva GI, Gelb MH. Pharmacological Characterization, Structural studies, and In Vivo Activity of Anti-Chagas Disease Lead Compounds Derived from Tipifarnib. Antimicrob Agents Chemother. 2012 Jul 9. PMID:22777048 doi:10.1128/AAC.06244-11
Categories: Sterol 14-demethylase | Trypanosoma brucei | Buckner, F S. | Gelb, M H. | Hargrove, T Y. | Kraus, J M. | Lepesheva, G I. | Waterman, M R. | Wawrzak, Z. | Cyp51 | Cytochrome p450 fold | Cytochrome p450 reductase | Endoplasmic reticulum membrane | Heme | Monooxygenase | Oxidoreductase | Sterol 14-alpha demethylase | Sterol biosynthesis
