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1a4f
From Proteopedia
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| - | [[Image:1a4f.gif|left|200px]] | + | [[Image:1a4f.gif|left|200px]] |
| - | + | ||
| - | '''BAR-HEADED GOOSE HEMOGLOBIN (OXY FORM)''' | + | {{Structure |
| + | |PDB= 1a4f |SIZE=350|CAPTION= <scene name='initialview01'>1a4f</scene>, resolution 2.0Å | ||
| + | |SITE= | ||
| + | |LIGAND= <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene> and <scene name='pdbligand=OXY:OXYGEN MOLECULE'>OXY</scene> | ||
| + | |ACTIVITY= | ||
| + | |GENE= | ||
| + | }} | ||
| + | |||
| + | '''BAR-HEADED GOOSE HEMOGLOBIN (OXY FORM)''' | ||
| + | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1A4F is a [ | + | 1A4F is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Anser_indicus Anser indicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A4F OCA]. |
==Reference== | ==Reference== | ||
| - | The crystal structure of a high oxygen affinity species of haemoglobin (bar-headed goose haemoglobin in the oxy form)., Zhang J, Hua Z, Tame JR, Lu G, Zhang R, Gu X, J Mol Biol. 1996 Jan 26;255(3):484-93. PMID:[http:// | + | The crystal structure of a high oxygen affinity species of haemoglobin (bar-headed goose haemoglobin in the oxy form)., Zhang J, Hua Z, Tame JR, Lu G, Zhang R, Gu X, J Mol Biol. 1996 Jan 26;255(3):484-93. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8568892 8568892] |
[[Category: Anser indicus]] | [[Category: Anser indicus]] | ||
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
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[[Category: respiratory protein]] | [[Category: respiratory protein]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 09:52:47 2008'' |
Revision as of 07:52, 20 March 2008
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| , resolution 2.0Å | |||||||
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| Ligands: | and | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
BAR-HEADED GOOSE HEMOGLOBIN (OXY FORM)
Overview
We have determined the crystal structure of bar-headed goose haemoglobin in the oxy form to a resolution of 2.0 A. The R-factor of the model is 19.8%. The structure is similar to human HbA, but contacts between the subunits show slightly altered packing of the tetramer. Bar-headed goose blood shows a greatly elevated oxygen affinity compared to closely related species of geese. This is apparently due to a single proline to alanine mutation at the alpha 1 beta 1 interface which destabilises the T state of the protein. The beta chain N and C termini are well-localized, and together with other neighbouring basic groups they form a strongly positively charged groove at the entrance to the central cavity around the molecular dyad. The well-ordered conformation and the three-dimensional distribution of positive charges clearly indicate this area to be the inositol pentaphosphate binding site of bird haemoglobins.
About this Structure
1A4F is a Protein complex structure of sequences from Anser indicus. Full crystallographic information is available from OCA.
Reference
The crystal structure of a high oxygen affinity species of haemoglobin (bar-headed goose haemoglobin in the oxy form)., Zhang J, Hua Z, Tame JR, Lu G, Zhang R, Gu X, J Mol Biol. 1996 Jan 26;255(3):484-93. PMID:8568892
Page seeded by OCA on Thu Mar 20 09:52:47 2008
Categories: Anser indicus | Protein complex | Gu, X. | Zhang, J. | HEM | OXY | Erythrocyte | Heme | Oxygen transport | Respiratory protein
