1a4s
From Proteopedia
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| - | [[Image:1a4s.gif|left|200px]] | + | [[Image:1a4s.gif|left|200px]] |
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| - | '''BETAINE ALDEHYDE DEHYDROGENASE FROM COD LIVER''' | + | {{Structure |
| + | |PDB= 1a4s |SIZE=350|CAPTION= <scene name='initialview01'>1a4s</scene>, resolution 2.10Å | ||
| + | |SITE= | ||
| + | |LIGAND= | ||
| + | |ACTIVITY= [http://en.wikipedia.org/wiki/Betaine-aldehyde_dehydrogenase Betaine-aldehyde dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.2.1.8 1.2.1.8] | ||
| + | |GENE= | ||
| + | }} | ||
| + | |||
| + | '''BETAINE ALDEHYDE DEHYDROGENASE FROM COD LIVER''' | ||
| + | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1A4S is a [ | + | 1A4S is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Gadus_callarias Gadus callarias]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A4S OCA]. |
==Reference== | ==Reference== | ||
| - | Structure of betaine aldehyde dehydrogenase at 2.1 A resolution., Johansson K, El-Ahmad M, Ramaswamy S, Hjelmqvist L, Jornvall H, Eklund H, Protein Sci. 1998 Oct;7(10):2106-17. PMID:[http:// | + | Structure of betaine aldehyde dehydrogenase at 2.1 A resolution., Johansson K, El-Ahmad M, Ramaswamy S, Hjelmqvist L, Jornvall H, Eklund H, Protein Sci. 1998 Oct;7(10):2106-17. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9792097 9792097] |
[[Category: Betaine-aldehyde dehydrogenase]] | [[Category: Betaine-aldehyde dehydrogenase]] | ||
[[Category: Gadus callarias]] | [[Category: Gadus callarias]] | ||
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[[Category: oxidoreductase]] | [[Category: oxidoreductase]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 09:52:53 2008'' |
Revision as of 07:52, 20 March 2008
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| , resolution 2.10Å | |||||||
|---|---|---|---|---|---|---|---|
| Activity: | Betaine-aldehyde dehydrogenase, with EC number 1.2.1.8 | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
BETAINE ALDEHYDE DEHYDROGENASE FROM COD LIVER
Overview
The three-dimensional structure of betaine aldehyde dehydrogenase, the most abundant aldehyde dehydrogenase (ALDH) of cod liver, has been determined at 2.1 A resolution by the X-ray crystallographic method of molecular replacement. This enzyme represents a novel structure of the highly multiple ALDH, with at least 12 distinct classes in humans. This betaine ALDH of class 9 is different from the two recently determined ALDH structures (classes 2 and 3). Like these, the betaine ALDH structure has three domains, one coenzyme binding domain, one catalytic domain, and one oligomerization domain. Crystals grown in the presence or absence of NAD+ have very similar structures and no significant conformational change occurs upon coenzyme binding. This is probably due to the tight interactions between domains within the subunit and between subunits in the tetramer. The oligomerization domains link the catalytic domains together into two 20-stranded pleated sheet structures. The overall structure is similar to that of the tetrameric bovine class 2 and dimeric rat class 3 ALDH, but the coenzyme binding with the nicotinamide in anti conformation, resembles that of class 2 rather than of class 3.
About this Structure
1A4S is a Single protein structure of sequence from Gadus callarias. Full crystallographic information is available from OCA.
Reference
Structure of betaine aldehyde dehydrogenase at 2.1 A resolution., Johansson K, El-Ahmad M, Ramaswamy S, Hjelmqvist L, Jornvall H, Eklund H, Protein Sci. 1998 Oct;7(10):2106-17. PMID:9792097
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