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1a7x

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[[Image:1a7x.gif|left|200px]]<br /><applet load="1a7x" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1a7x.gif|left|200px]]
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caption="1a7x, resolution 2.0&Aring;" />
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'''FKBP12-FK1012 COMPLEX'''<br />
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{{Structure
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|PDB= 1a7x |SIZE=350|CAPTION= <scene name='initialview01'>1a7x</scene>, resolution 2.0&Aring;
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|SITE=
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|LIGAND= <scene name='pdbligand=FKA:BENZYL-CARBAMIC ACID [8-DEETHYL-ASCOMYCIN-8-YL]ETHYL ESTER'>FKA</scene>
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|ACTIVITY= [http://en.wikipedia.org/wiki/Peptidylprolyl_isomerase Peptidylprolyl isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.2.1.8 5.2.1.8]
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|GENE=
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}}
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'''FKBP12-FK1012 COMPLEX'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1A7X is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=FKA:'>FKA</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Peptidylprolyl_isomerase Peptidylprolyl isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.2.1.8 5.2.1.8] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A7X OCA].
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1A7X is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A7X OCA].
==Reference==
==Reference==
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Chemical inducers of dimerization: the atomic structure of FKBP12-FK1012A-FKBP12., Schultz LW, Clardy J, Bioorg Med Chem Lett. 1998 Jan 6;8(1):1-6. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9871618 9871618]
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Chemical inducers of dimerization: the atomic structure of FKBP12-FK1012A-FKBP12., Schultz LW, Clardy J, Bioorg Med Chem Lett. 1998 Jan 6;8(1):1-6. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9871618 9871618]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Peptidylprolyl isomerase]]
[[Category: Peptidylprolyl isomerase]]
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[[Category: isomerase]]
[[Category: isomerase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 11:41:50 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 09:54:10 2008''

Revision as of 07:54, 20 March 2008

Image:1a7x.gif


PDB ID 1a7x

Drag the structure with the mouse to rotate
, resolution 2.0Å
Ligands:
Activity: Peptidylprolyl isomerase, with EC number 5.2.1.8
Coordinates: save as pdb, mmCIF, xml



FKBP12-FK1012 COMPLEX


Overview

A ligand that simultaneously binds two proteins must have two high affinity protein binding domains joined in a fashion that facilitates, or at least does not prevent, protein-protein interaction. Designing such ligands is challenging, and a high resolution X-ray structure of FKBP12-FK1012A-FKBP12 illustrates the subtleties of one successful design.

About this Structure

1A7X is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Chemical inducers of dimerization: the atomic structure of FKBP12-FK1012A-FKBP12., Schultz LW, Clardy J, Bioorg Med Chem Lett. 1998 Jan 6;8(1):1-6. PMID:9871618

Page seeded by OCA on Thu Mar 20 09:54:10 2008

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