1a9m

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[[Image:1a9m.gif|left|200px]]<br /><applet load="1a9m" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1a9m.gif|left|200px]]
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caption="1a9m, resolution 2.3&Aring;" />
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'''G48H MUTANT OF HIV-1 PROTEASE IN COMPLEX WITH A PEPTIDIC INHIBITOR U-89360E'''<br />
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{{Structure
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|PDB= 1a9m |SIZE=350|CAPTION= <scene name='initialview01'>1a9m</scene>, resolution 2.3&Aring;
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|SITE=
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|LIGAND= <scene name='pdbligand=U0E:N-[[1-[N-ACETAMIDYL]-[1-CYCLOHEXYLMETHYL-2-HYDROXY-4-ISOPROPYL]-BUT-4-YL]-CARBONYL]-GLUTAMINYL-ARGINYL-AMIDE'>U0E</scene>
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|ACTIVITY=
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|GENE=
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}}
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'''G48H MUTANT OF HIV-1 PROTEASE IN COMPLEX WITH A PEPTIDIC INHIBITOR U-89360E'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1A9M is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus Human immunodeficiency virus] with <scene name='pdbligand=U0E:'>U0E</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A9M OCA].
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1A9M is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus Human immunodeficiency virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A9M OCA].
==Reference==
==Reference==
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Structure of a G48H mutant of HIV-1 protease explains how glycine-48 replacements produce mutants resistant to inhibitor drugs., Hong L, Zhang XJ, Foundling S, Hartsuck JA, Tang J, FEBS Lett. 1997 Dec 22;420(1):11-6. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9450540 9450540]
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Structure of a G48H mutant of HIV-1 protease explains how glycine-48 replacements produce mutants resistant to inhibitor drugs., Hong L, Zhang XJ, Foundling S, Hartsuck JA, Tang J, FEBS Lett. 1997 Dec 22;420(1):11-6. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9450540 9450540]
[[Category: Human immunodeficiency virus]]
[[Category: Human immunodeficiency virus]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: mutation]]
[[Category: mutation]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 11:42:20 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 09:54:50 2008''

Revision as of 07:54, 20 March 2008

Image:1a9m.gif


PDB ID 1a9m

Drag the structure with the mouse to rotate
, resolution 2.3Å
Ligands:
Coordinates: save as pdb, mmCIF, xml



G48H MUTANT OF HIV-1 PROTEASE IN COMPLEX WITH A PEPTIDIC INHIBITOR U-89360E


Overview

The crystal structure of human immunodeficiency virus type 1 (HIV-1) protease mutant G48H with peptidic inhibitor U-89360E is described. Comparison with wild-type protease-inhibitor complex shows that mutation of flap residue 48 to histidine allows stabilizing van der Waals contacts between the side chains of His48 and Phe53 as well as between His48 and the P2' and P3' inhibitor subsites. The flap region is less mobile than in the wild-type enzyme. A model of saquinavir-resistant mutant protease G48V in complex with saquinavir predicts interactions similar to those found in the G48H crystal. Energetic calculations confirm the similarity of the His48 and Val48 interactions.

About this Structure

1A9M is a Single protein structure of sequence from Human immunodeficiency virus. Full crystallographic information is available from OCA.

Reference

Structure of a G48H mutant of HIV-1 protease explains how glycine-48 replacements produce mutants resistant to inhibitor drugs., Hong L, Zhang XJ, Foundling S, Hartsuck JA, Tang J, FEBS Lett. 1997 Dec 22;420(1):11-6. PMID:9450540

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